Ubertino of Casale (1259 – c. 1329) was an Italian Franciscan and one of the leaders (together with Michael of Cesena) of the Spirituals, the stricter branch of the Franciscan order.
Ubertino was born in Casale Monferrato. He became a disciple of Peter Olivi, a leading Spiritual, and later became leader of the Spirituals in Tuscany. The Spirituals espoused poverty as obligatory and insisted on a stricter interpretation of the Rule of St. Francis. They attacked Popes Gregory IX and Nicholas III, who had favoured a moderate interpretation of the rule, and Pope Innocent III, who had disapproved of the teaching of Joachim of Fiore, as heretics. Therefore, Ubertino was summoned before Pope Benedict XI, forbidden to preach at Perugia, and banished to the convent of Monte Alverna.
During his banishment, Ubertino wrote the Arbor Vitae Crucifixae Jesu Christi (The Tree of the Crucified Life of Jesus), exalting a literal interpretation of the Rule of St. Francis and the poverty of Christ. In the book, Ubertino identified Pope Boniface VIII, another opponent of the Spirituals, and Benedict XI as the first and second beast of the Apocalypse.
In 1307, he was chosen chaplain and familiar to cardinal Napoleone Orsini Frangipani, formerly a protector of the Spirituals. In 1308, when Orsini went to Germany, Ubertino moved to France. In 1312-13, he was called to Avignon with other chiefs of the Spirituals to discuss before the pope the questions at issue between the two parties in the order. During discussions, he attacked the moderate majority of his order and demanded separate convents and provinces for his party. But this was absolutely denied, whilst on the other hand the question of practical observance of poverty was settled by the famous Bull Exivi de paradiso, 6 May 1312, partly called forth by the polemical writings of Ubertino.