UNC93B1

UNC93B1
Identifiers
Aliases	UNC93B1, IIAE1, UNC93, UNC93B, Unc-93B1, unc-93 homolog B1 (C. elegans), unc-93 homolog B1, TLR signaling regulator
External IDs	MGI: 1859307 HomoloGene: 41325 GeneCards: UNC93B1
Gene location (Human) Chr. Chromosome 11 (human) Band 11q13.2 Start 67,991,104 bp End 68,004,982 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19|19 A Start 3,935,186 bp End 3,949,340 bp
Gene ontology Molecular function • Toll-like receptor binding Cellular component • integral component of membrane • early phagosome • Golgi membrane • endosome • lysosome • phagocytic vesicle • endoplasmic reticulum membrane • endoplasmic reticulum • membrane • cytoplasmic vesicle Biological process • toll-like receptor 9 signaling pathway • intracellular protein transport • toll-like receptor 3 signaling pathway • adaptive immune response • defense response to virus • toll-like receptor 7 signaling pathway • toll-like receptor signaling pathway • immune system process • innate immune response Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	81622	54445
Ensembl	ENSG00000110057	ENSMUSG00000036908
UniProt	Q9H1C4	Q8VCW4
RefSeq (mRNA)	NM_030930	NM_001161428 NM_019449
RefSeq (protein)	NP_112192	NP_001154900 NP_062322
Location (UCSC)	Chr 11: 67.99 – 68 Mb	Chr 11: 3.94 – 3.95 Mb
PubMed search

81622

54445

ENSG00000110057

ENSMUSG00000036908

Q9H1C4

Q8VCW4

NM_030930

NM_001161428
NM_019449

NP_112192

NP_001154900
NP_062322

Unc-93 homolog B1 (C. elegans), also known as UNC93B1, is a protein which in humans is encoded by the UNC93B1 gene.

This gene encodes a protein with similarity to the Caenorhabditis elegans unc93 protein. The Unc93 protein is involved in the regulation or coordination of muscle contraction in the worm.

The gene is located on long arm of chromosome 11 (11q13) on the minus (Crick) strand and was first identified in 2002. This protein is an intrinsic membrane protein that spans the membrane twelve times. It is found in the endoplasmic reticulum and is highly conserved.

Unc93B1 protein appears to be involved in the innate immune response. Defects in the protein predispose to hypersensitity to infections with herpes simplex virus and mouse cytomegalovirus. The mechanism is unclear but Unc93B1 is known to interact with the toll-like receptors TLR3, TLR7 and TLR9 and it appears to be involved in the trafficking of these receptors within the cell. Mutations in this gene lead to selective impairment of dsRNA-induced interferon alpha/beta and interferon 1 lambda production.

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Wikipedia