TLR9

Identifiers

TLR9, CD289, toll like receptor 9

External IDs

OMIM: 605474 MGI: 1932389 HomoloGene: 68126 GeneCards: TLR9

Gene ontology
Molecular function	• siRNA binding • interleukin-1 receptor binding • transmembrane signaling receptor activity • 1-phosphatidylinositol-3-kinase activity • protein homodimerization activity • unmethylated CpG binding
Cellular component	• cytoplasm • integral component of membrane • endosome • endoplasmic reticulum membrane • membrane • early phagosome • Golgi membrane • plasma membrane • extracellular region • basolateral plasma membrane • apical plasma membrane • endoplasmic reticulum • phagocytic vesicle • endolysosome membrane • lysosome • endosome membrane • cytoplasmic vesicle • proteinaceous extracellular matrix • extracellular space
Biological process	• positive regulation of interleukin-18 production • positive regulation of toll-like receptor signaling pathway • positive regulation of inflammatory response • positive regulation of interleukin-12 production • axonogenesis • positive regulation of interleukin-10 production • immune system process • positive regulation of JUN kinase activity • positive regulation of interferon-gamma biosynthetic process • regulation of cytokine secretion • positive regulation of interferon-beta biosynthetic process • negative regulation of interleukin-6 production • I-kappaB phosphorylation • positive regulation of JNK cascade • positive regulation of nitric-oxide synthase biosynthetic process • MyD88-dependent toll-like receptor signaling pathway • negative regulation of interleukin-8 production • positive regulation of gene expression • negative regulation of calcium-transporting ATPase activity • negative regulation of toll-like receptor signaling pathway • defense response to bacterium • maintenance of gastrointestinal epithelium • positive regulation of granulocyte macrophage colony-stimulating factor production • defense response to Gram-negative bacterium • positive regulation of NF-kappaB transcription factor activity • positive regulation of interleukin-8 production • positive regulation of interleukin-6 production • positive regulation of tumor necrosis factor production • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of chemokine production • tumor necrosis factor production • toll-like receptor 9 signaling pathway • positive regulation of interferon-alpha biosynthetic process • positive regulation of NF-kappaB import into nucleus • innate immune response • inflammatory response • response to molecule of bacterial origin • negative regulation of NF-kappaB transcription factor activity • positive regulation of transcription from RNA polymerase II promoter • signal transduction • positive regulation of interferon-beta production • toll-like receptor signaling pathway • phosphatidylinositol-3-phosphate biosynthetic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


54106


81897

Ensembl


ENSG00000239732


ENSMUSG00000045322

UniProt


Q9NR96


Q9EQU3

RefSeq (mRNA)


NM_138688 NM_017442


NM_031178

RefSeq (protein)


NP_059138


NP_112455.2 NP_112455

Location (UCSC)

Chr 3: 52.22 – 52.23 Mb

Chr 9: 106.22 – 106.23 Mb

PubMed search

NP_112455.2
NP_112455

Toll-like receptor 9 is a protein that in humans is encoded by the TLR9 gene. TLR9 has also been designated as CD289 (cluster of differentiation 289). It is a member of the toll-like receptor (TLR) family. TLR9 is an important receptor expressed in immune system cells including dendritic cells, macrophages, natural killer cells, and other antigen presenting cells. TLR9 preferentially binds DNA present in bacteria and viruses, and triggers signaling cascades that lead to a pro-inflammatory cytokine response. Cancer, infection, and tissue damage can all modulate TLR9 expression and activation. TLR9 is also an important factor in autoimmune diseases, and there is active research into synthetic TLR9 agonists and antagonists that help regulate autoimmune inflammation.

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Wikipedia