ULK1

ULK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4WNO, 4WNP, 5CI7
Identifiers
Aliases	ULK1, ATG1, ATG1A, UNC51, Unc51.1, hATG1, unc-51 like autophagy activating kinase 1
External IDs	MGI: 1270126 HomoloGene: 2640 GeneCards: ULK1
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • protein complex binding • protein serine/threonine kinase activity • Rab GTPase binding • protein binding • ATP binding • kinase activity • GTPase binding Cellular component • cytoplasm • cytosol • pre-autophagosomal structure membrane • extrinsic component of omegasome membrane • ATG1/ULK1 kinase complex • extrinsic component of pre-autophagosomal structure membrane • pre-autophagosomal structure • autophagosome • extrinsic component of autophagosome membrane • endoplasmic reticulum membrane • recycling endosome • guanyl-nucleotide exchange factor complex • mitochondrial outer membrane Biological process • neuron projection regeneration • protein localization • axonogenesis • phosphorylation • negative regulation of protein complex assembly • protein phosphorylation • peptidyl-serine phosphorylation • cellular response to nutrient levels • axon extension • response to starvation • protein autophosphorylation • neuron projection development • signal transduction • autophagy • macroautophagy • membrane organization • peptidyl-threonine phosphorylation • regulation of macroautophagy • autophagy of host cells involved in interaction with symbiont Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8408	22241
Ensembl	ENSG00000177169	ENSMUSG00000029512
UniProt	O75385	O70405
RefSeq (mRNA)	NM_003565	NM_009469 NM_001347394
RefSeq (protein)	NP_003556	NP_033495.2 NP_001334323 NP_033495
Location (UCSC)	Chr 12: 131.89 – 131.92 Mb	Chr 5: 110.78 – 110.81 Mb
PubMed search

4WNO, 4WNP, 5CI7

8408

22241

ENSG00000177169

ENSMUSG00000029512

O75385

O70405

NM_003565

NM_009469
NM_001347394

NP_003556

NP_033495.2
NP_001334323
NP_033495

Serine/threonine-protein kinase ULK1 is an enzyme that in humans is encoded by the ULK1 gene.

ULK1 is an important protein in autophagy. It is part of the ULK1-complex, which is needed in early steps of autophagosome biogenesis.

ULK1 has been shown to interact with GABARAPL2,GABARAP,SYNGAP1 and SDCBP.

...
Wikipedia