UHMK1

UHMK1
Identifiers
Aliases	UHMK1, KIS, KIST, P-CIP2, U2AF homology motif (UHM) kinase 1
External IDs	MGI: 1341908 HomoloGene: 7801 GeneCards: UHMK1
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • kinase activity • protein serine/threonine kinase activity • protein binding • RNA binding • nucleic acid binding • ribonucleoprotein complex binding • ATP binding • poly-pyrimidine tract binding • pre-mRNA 3'-splice site binding Cellular component • ribonucleoprotein granule • axon • neuronal ribonucleoprotein granule • dendrite cytoplasm • nucleus • nucleoplasm • Golgi apparatus • commitment complex • nuclear speck • U2-type prespliceosome • U2AF Biological process • regulation of protein export from nucleus • phosphorylation • protein phosphorylation • peptidyl-serine phosphorylation • cell cycle arrest • protein autophosphorylation • neuron projection development • positive regulation of translational initiation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	127933	16589
Ensembl	ENSG00000152332	ENSMUSG00000026667
UniProt	Q8TAS1	P97343
RefSeq (mRNA)	NM_001184763 NM_144624 NM_175866	NM_010633
RefSeq (protein)	NP_001171692 NP_653225 NP_787062	NP_034763.3 NP_034763
Location (UCSC)	Chr 1: 162.5 – 162.53 Mb	Chr 1: 170.19 – 170.22 Mb
PubMed search

127933

16589

ENSG00000152332

ENSMUSG00000026667

Q8TAS1

P97343

NM_001184763
NM_144624
NM_175866

NM_010633

NP_001171692
NP_653225
NP_787062

NP_034763.3
NP_034763

U2AF homology motif (UHM) kinase 1, also known as UHMK1, is a protein which in humans is encoded by the UHMK1 gene.

UHMK1 is a kinase enzyme which phosphorylates the protein stathmin and has an RNA recognition motif of unknown function.

UHMK1 is highly expressed in the brain and has been genetically implicated in schizophrenia in two genetic studies. Mice with the gene encoding stathmin knocked out, so that they do not express this protein in the brain, show abnormal fear responses. This effect could be developed as an animal model for schizophrenia. UHMK1 also phosphorylates the CNS proteins myelin basic protein (MBP) and synapsin I so that genetic abnormalities in UHMK1 could contribute to the genetic cause of schizophrenia through several different brain pathways.

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Wikipedia