UGT1A9

UGT1A9
Identifiers
Aliases	UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT 1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I, UGT1A9S, UDP glucuronosyltransferase family 1 member A9
External IDs	MGI: 3576092 HomoloGene: 133281 GeneCards: UGT1A9
Gene location (Human) Chr. Chromosome 2 (human) Band No data available Start 233,671,853 bp End 233,773,300 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band No data available Start 88,070,800 bp End 88,218,997 bp
Gene ontology Molecular function • transferase activity • enzyme inhibitor activity • retinoic acid binding • transferase activity, transferring hexosyl groups • protein homodimerization activity • transferase activity, transferring glycosyl groups • glucuronosyltransferase activity • protein heterodimerization activity • enzyme binding Cellular component • integral component of membrane • endoplasmic reticulum membrane • membrane • intracellular membrane-bounded organelle • endoplasmic reticulum • extracellular exosome Biological process • retinoic acid metabolic process • negative regulation of cellular glucuronidation • cellular glucuronidation • flavonoid glucuronidation • xenobiotic glucuronidation • flavone metabolic process • drug metabolic process • xenobiotic metabolic process • metabolic process • negative regulation of glucuronosyltransferase activity • negative regulation of fatty acid metabolic process • regulation of lipid metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54600	394434
Ensembl	ENSG00000241119	ENSMUSG00000090175
UniProt	O60656	Q62452
RefSeq (mRNA)	NM_021027	NM_201644
RefSeq (protein)	NP_066307	NP_964006
Location (UCSC)	Chr 2: 233.67 – 233.77 Mb	Chr 2: 88.07 – 88.22 Mb
PubMed search

54600

394434

ENSG00000241119

ENSMUSG00000090175

O60656

Q62452

NM_021027

NM_201644

NP_066307

NP_964006

UDP-glucuronosyltransferase 1-9 is an enzyme that in humans is encoded by the UGT1A9 gene.

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5′ exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenols.

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