U.S. Route 322 in Pennsylvania
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Route highlighted in red
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| Route information | ||||
| Maintained by PennDOT | ||||
| Length: | 370 mi (595 km) | |||
| Major junctions | ||||
| West end: |
 US 322 at Ohio border in West Shenango Township
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 I-79 in Meadville I-80 in Clarion Township  I-99 / US 220 in State College  US 22 / US 522 in Lewistown  US 11 / US 15 in Duncannon I-81 in Harrisburg I-83 in Harrisburg US 30 in Downingtown US 1 in Concordville I-95 in Chester
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| East end: |
US 322 at the Commodore Barry Bridge at New Jersey border in Chester
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| Location | ||||
| Counties: | Crawford, Mercer, Venango, Clarion, Jefferson, Clearfield, Centre, Mifflin, Juniata, Perry, Dauphin, Lebanon, Lancaster, Chester, Delaware | |||
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U.S. Route 322 (US 322) is a U.S. highway running from Cleveland, Ohio east to Atlantic City, New Jersey. In the U.S. state of Pennsylvania, the route runs from the Ohio border in West Shenango Township southeast to the Commodore Barry Bridge over the Delaware River in Chester, at which point the route crosses into New Jersey. The route passes near several cities, including DuBois, State College, and Harrisburg.
In Pennsylvania, US 322 is signed as 28th Division Highway, in honor of the 28th Infantry Division. The route enters Pennsylvania taking a northeasternly course. In Meadville, US 322 overlaps U.S. Route 6 and U.S. Route 19. Southeast of Meadville, the highway runs generally southeast through Crawford, Venango and Clarion Counties. Once leaving Clarion borough, US 322 interchanges I-80, at exit 70. From I-80, it continues on a solid east–west routing crossing Jefferson County. The route overlaps U.S. Route 219 near the northern terminus of U.S. Route 119, south of Du Bois. East of US 219, the route takes a southward turn to traverse Moshannon State Forest, before taking an east–west alignment. From Clearfield to U.S. Route 220, the highway runs southeast and is partly divided.
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