U.S. Route 222 Business (Reading, Pennsylvania)
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| Route information | |
| Business route of US 222 | |
| Maintained by PennDOT | |
| Length: | 12.173 mi (19.591 km) |
| Existed: | 1975 – present |
| Major junctions | |
| South end: |
 US 222 in Cumru Township
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 PA 724 in Shillington PA 625 in Reading PA 10 in Reading US 422 in Reading   US 422 Bus. in Reading PA 61 in Reading PA 12 in Muhlenberg Township
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| North end: |
US 222 in Ontelaunee Township
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| Location | |
| Counties: | Berks |
| Highway system | |
U.S. Route 222 Business (US 222 Bus.) is a 12.17-mile (19.59 km) business route of US 222 located in Reading, Pennsylvania. The southern terminus is at US 222 in Cumru Township. Its northern terminus is at US 222 in Ontelaunee Township. The route begins at the US 222 freeway and heads through the southwestern suburbs of Reading as Lancaster Avenue, intersecting Pennsylvania Route 724 (PA 724) in Shillington. US 222 Bus. continues into Reading on Lancaster Avenue and intersects the northern termini of PA 625 and PA 10 before reaching an interchange with the US 422 freeway. The business route crosses the Schuylkill River and becomes Bingaman Street. US 222 Bus. turns north on 5th Street and intersects US 422 Bus. in downtown Reading and the southern terminus of PA 61 to the north of downtown. The route interchanges with the PA 12 freeway and continues north through suburban Muhlenberg Township as 5th Street Highway. US 222 Bus. reaches Temple and continues northeast to its northern terminus as Allentown Pike. US 222 Bus. is the only auxiliary route of US 222 in Pennsylvania.
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