U.S. Highway 341
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| Route information | |
| Auxiliary route of US 41 | |
| Length: | 224 mi (360 km) |
| Existed: | 1926 – present |
| Major junctions | |
| South end: |
 US 17 in Brunswick
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 US 25 in Brunswick I‑95 in Brunswick  US 25 / US 84 / US 301 in Jesup US 1 in Baxley  US 23 / US 221 in HazlehurstUS 23 in Eastman US 41 in Perry I‑75 in Perry US 80 in Knoxville
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| North end: |
US 41 in Barnesville
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| Location | |
| Counties: | Glynn, Wayne, Appling, Jeff Davis, Telfair, Pulaski, Houston, Peach, Crawford, Monroe, Lamar |
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| Location: | Eastman |
| Length: | 4.1 mi (6.6 km) |
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| Location: | Hawkinsville |
| Length: | 1.4 mi (2.3 km) |
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| Location: | Perry |
| Length: | 6.2 mi (10.0 km) |
U.S. Route 341 (US 341) is a 224-mile-long (360 km) U.S. highway entirely in the U.S. state of Georgia. It runs diagonally across southern Georgia (but is signed as north–south) from Brunswick at US 17 to Barnesville at US 41. It is a spur route of US 41 and has two intersections with it: in Perry and at its northern terminus in Barnesville.
US 341 is a part of the National Highway System from its southern terminus in Brunswick north to SR 224 near Perry.
US 341 begins at an intersection with US 17 and SR 25 (Glynn Avenue) in the southeast corner of the city of Brunswick, a short distance north of the Sidney Lanier Bridge. US 341 and its state route companion, SR 27, head west along 4th Street, a four-lane undivided street. The highway turns north onto Newcastle Street and passes along the edge of the Port of Brunswick. Newcastle Street becomes two lanes at 1st Avenue; US 341 turns west onto Prince Street then north onto Bay Street, which becomes a four-lane divided highway immediately to the south of the intersection. The highway parallels Norfolk Southern Railway's Brunswick District north between downtown Brunswick to the east and an industrial area along the East River. At the north end of downtown, US 341 has an oblique intersection with US 25 (Newcastle Street), whose companion route is SR 25 Connector and which serves as the main street of downtown Brunswick.
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