U.S. Highway 221

U.S. Route 221
Route information
Auxiliary route of US 21
Length:	734 mi (1,181 km)
Existed:	1930 – present
Major junctions
South end:	US 19 / US 27 Alt. / US 98 / SR 55 in Perry, FL
	I-10 near Greenville, FL I‑75 in Valdosta, GA I‑16 near Soperton, GA I‑20 near Harlem, GA I-385 near Laurens, SC I-26 in Roebuck, SC I-85 in Spartanburg, SC I‑40 in Marion, NC I‑77 near Hillsville, VA I‑581 in Roanoke, VA
North end:	US 29 Bus. / US 460 Bus. / US 501 Bus. at Lynchburg, VA
Location
States:	Florida, Georgia, South Carolina, North Carolina, Virginia
Highway system
United States Numbered Highway System List Special Divided Replaced

U.S. Route 221 is a spur of U.S. Route 21. It runs for 734 miles (1,181 km) from Perry, Florida, at U.S. Routes 19/98/27 Alternate to Lynchburg, Virginia, at U.S. Route 29 (Lynchburg Expressway). It passes through the states of Florida, Georgia, South Carolina, North Carolina, and Virginia. It goes through the cities of Valdosta, Georgia; Spartanburg, South Carolina; Marion, North Carolina; Roanoke, Virginia; and Lynchburg, Virginia.

Throughout western North Carolina from the Virginia border to the Blue Ridge Parkway, U.S. 221 is a challenging drive, and can be described as one climb after another. There are few places where the road builders attempted to skirt around large foothills.

U.S. Route 221 originates just south of the city of Perry with its southern terminus intersecting with the cosigned U.S. Route 19 U.S. Route 98 and U.S. Route 27 Alternate, taking hidden SR 55 with it away from US 19. It continues through the city of Perry and intersects Interstate 10 and U.S. Route 90 in rural Madison County before crossing into Georgia.

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