Twist transcription factor

TWIST1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MJV
Identifiers
Aliases	TWIST1, twist family bHLH transcription factor 1, ACS3, BPES2, BPES3, CRS, CRS1, SCS, TWIST, bHLHa38, CSO
External IDs	OMIM: 601622 MGI: 98872 HomoloGene: 402 GeneCards: TWIST1
Genetically Related Diseases
obesity
Gene ontology Molecular function • DNA binding • protein dimerization activity • protein homodimerization activity • protein domain specific binding • transcription factor activity, sequence-specific DNA binding • transcription factor binding • bHLH transcription factor binding • E-box binding • protein binding • protein heterodimerization activity • RNA polymerase II transcription factor activity, sequence-specific DNA binding Cellular component • nucleus • nucleoplasm Biological process • positive regulation of transcription regulatory region DNA binding • embryonic skeletal system morphogenesis • positive regulation of fatty acid beta-oxidation • palate development • cell differentiation • positive regulation of cell motility • regulation of transcription, DNA-templated • negative regulation of molecular function • positive regulation of interleukin-6 secretion • ossification • rhythmic process • positive regulation of epithelial cell proliferation • negative regulation of striated muscle tissue development • regulation of bone mineralization • aortic valve morphogenesis • negative regulation of cell differentiation • cardiac neural crest cell migration involved in outflow tract morphogenesis • cellular response to growth factor stimulus • positive regulation of monocyte chemotactic protein-1 production • muscle organ development • embryonic digit morphogenesis • negative regulation of apoptotic process • neuron migration • in utero embryonic development • negative regulation of transcription from RNA polymerase II promoter • outer ear morphogenesis • eyelid development in camera-type eye • mitral valve morphogenesis • positive regulation of DNA-templated transcription, initiation • positive regulation of epithelial to mesenchymal transition • negative regulation of sequence-specific DNA binding transcription factor activity • transcription, DNA-templated • negative regulation of osteoblast differentiation • positive regulation of angiogenesis • hindlimb morphogenesis • negative regulation of phosphatidylinositol 3-kinase signaling • cranial suture morphogenesis • odontogenesis • endocardial cushion morphogenesis • negative regulation of double-strand break repair • multicellular organism development • cardiac neural crest cell development involved in outflow tract morphogenesis • negative regulation of histone phosphorylation • neural tube closure • positive regulation of gene expression • negative regulation of DNA damage response, signal transduction by p53 class mediator • negative regulation of skeletal muscle tissue development • embryonic limb morphogenesis • negative regulation of oxidative phosphorylation uncoupler activity • osteoblast differentiation • positive regulation of tumor necrosis factor production • cell proliferation involved in heart valve development • embryonic cranial skeleton morphogenesis • negative regulation of tumor necrosis factor production • negative regulation of peroxisome proliferator activated receptor signaling pathway • positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation • negative regulation of histone acetylation • embryonic camera-type eye formation • bone development • embryonic forelimb morphogenesis • cellular response to hypoxia • positive regulation of transcription from RNA polymerase II promoter • negative regulation of cellular senescence • embryonic hindlimb morphogenesis • negative regulation of transcription, DNA-templated Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7291	22160
Ensembl	ENSG00000122691	ENSMUSG00000035799
UniProt	Q15672	P26687
RefSeq (mRNA)	NM_000474	NM_011658
RefSeq (protein)	NP_000465	NP_035788.1 NP_035788
Location (UCSC)	Chr 7: 19.02 – 19.12 Mb	Chr 12: 33.96 – 33.96 Mb
PubMed search

2MJV

7291

22160

ENSG00000122691

ENSMUSG00000035799

Q15672

P26687

NM_000474

NM_011658

NP_000465

NP_035788.1
NP_035788

Twist-related protein 1 (TWIST1) also known as class A basic helix-loop-helix protein 38 (bHLHa38) is a basic helix-loop-helix transcription factor that in humans is encoded by the TWIST1 gene.

Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, Dermo1 (a.k.a. TWIST2). The strongest expression of this mRNA is in placental tissue; in adults, mesodermally derived tissues express this mRNA preferentially.

Twist1 is thought to regulate osteogenic lineage.

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