TWIST2

TWIST2
Identifiers
Aliases	TWIST2, DERMO1, FFDD3, SETLSS, bHLHa39, AMS, BBRSAY, twist family bHLH transcription factor 2
External IDs	MGI: 104685 HomoloGene: 40594 GeneCards: TWIST2
Gene ontology Molecular function • DNA binding • protein binding • protein dimerization activity Cellular component • cytoplasm • nucleus • nucleolus Biological process • multicellular organism development • cell differentiation • negative regulation of apoptotic process • negative regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • negative regulation of osteoblast differentiation • transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	117581	13345
Ensembl	ENSG00000233608	ENSMUSG00000007805
UniProt	Q8WVJ9	Q9D030
RefSeq (mRNA)	NM_001271893 NM_057179	NM_007855
RefSeq (protein)	NP_001258822 NP_476527	NP_031881.1 NP_031881
Location (UCSC)	Chr 2: 238.85 – 238.91 Mb	Chr 1: 91.8 – 91.85 Mb
PubMed search

117581

13345

ENSG00000233608

ENSMUSG00000007805

Q8WVJ9

Q9D030

NM_001271893
NM_057179

NM_007855

NP_001258822
NP_476527

NP_031881.1
NP_031881

Twist-related protein 2 is a protein that in humans is encoded by the TWIST2 gene.

Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, Twist. It is thought that during osteoblast development this protein may inhibit osteoblast maturation and maintain cells in a preosteoblast phenotype.

TWIST2 has been shown to interact with SREBF1.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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