SREBF1

SREBF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AM9
Identifiers
Aliases	SREBF1, SREBP-1c, SREBP1, bHLHd1, SREBP1a, sterol regulatory element binding transcription factor 1
External IDs	MGI: 107606 HomoloGene: 3079 GeneCards: SREBF1
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • protein dimerization activity • transcription factor activity, sequence-specific DNA binding • protein complex binding • sterol response element binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • chromatin binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein binding • transcription regulatory region DNA binding • protein kinase binding • RNA polymerase II regulatory region sequence-specific DNA binding • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding Cellular component • cytoplasm • integral component of membrane • cytosol • Golgi apparatus • nuclear envelope • endoplasmic reticulum membrane • membrane • intracellular membrane-bounded organelle • Golgi membrane • nucleoplasm • protein complex • endoplasmic reticulum • ER to Golgi transport vesicle membrane • cytoplasmic vesicle • nucleus Biological process • positive regulation of histone deacetylation • insulin receptor signaling pathway • positive regulation of triglyceride biosynthetic process • steroid metabolic process • negative regulation of insulin secretion • response to fatty acid • lipid biosynthetic process • response to glucagon • regulation of protein stability • regulation of transcription, DNA-templated • response to retinoic acid • response to organic cyclic compound • lung development • lipid metabolic process • regulation of insulin secretion • regulation of transcription from RNA polymerase II promoter • cellular response to starvation • response to progesterone • aging • response to peptide hormone • mRNA transcription from RNA polymerase II promoter • cholesterol metabolic process • negative regulation of transcription from RNA polymerase II promoter • response to glucose • transcription, DNA-templated • positive regulation of transcription, DNA-templated • response to lipid • cellular response to fatty acid • regulation of mitophagy • regulation of protein targeting to mitochondrion • regulation of fatty acid metabolic process • circadian rhythm • cellular response to insulin stimulus • response to food • positive regulation of cholesterol biosynthetic process • response to cAMP • regulation of heart rate by chemical signal • fat cell differentiation • response to drug • intracellular receptor signaling pathway • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6720	20787
Ensembl	ENSG00000072310	ENSMUSG00000020538
UniProt	P36956	Q9WTN3
RefSeq (mRNA)	NM_001005291 NM_004176 NM_001321096	NM_011480 NM_001313979
RefSeq (protein)	NP_001005291 NP_001308025 NP_004167	NP_001300908.1 NP_035610.1 NP_001300908 NP_035610
Location (UCSC)	Chr 17: 17.81 – 17.84 Mb	Chr 11: 60.2 – 60.22 Mb
PubMed search

1AM9

6720

20787

ENSG00000072310

ENSMUSG00000020538

P36956

Q9WTN3

NM_001005291
NM_004176
NM_001321096

NM_011480
NM_001313979

NP_001005291
NP_001308025
NP_004167

NP_001300908.1
NP_035610.1
NP_001300908
NP_035610

Sterol regulatory element-binding transcription factor 1 (SREBF1) also known as sterol regulatory element-binding protein 1 (SREBP-1) is a protein that in humans is encoded by the SREBF1 gene.

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