Tugaloo was a Cherokee town on the Tugaloo River, at the mouth of Toccoa Creek, near present-day and Travelers Rest in Stephens County, Georgia.
The town's proper name, in Cherokee, was Dugiluyi (ᏚᎩᎷᏱ), abbreviated to Dugilu (ᏚᎩᎷ). In English it was spelled variously as Tugaloo, Toogelah, Toogoola, etc. Its meaning in Cherokee is uncertain, but seems to refer to a "place at the forks of a stream".
Tugaloo was one of the Chickamauga Cherokee "Lower Towns", the principal one being Keowee. The terms "Lower Towns" and "Lower Cherokee" were given by the English colonists to refer to the Cherokee who lived on the Keowee River, Tugaloo River, and other headstreams of the Savannah River. The terms correspond in general with the Eastern Dialect of Cherokee, which was originally spoken by what the English called the Lower Cherokee in the region of the Lower Towns.
Gen. James Moore ordered an expedition into the lower Cherokee towns in 1715. The expedition, led by Col. Maurice Moore, left Fort Moore and arrived at Tugaloo on December 29, 1715. The expedition left Tugaloo on New Year's Day, 1716, for Nacoochee, and passed through Toccoa. Indian agent George Chicken was part of the expedition, and described Tugaloo as "the most ancient town in these parts." Col. Chicken convinced the Cherokee leaders to fight against the Savannas, Yuchis, and Apalachees. The Cherokees killed eleven Lower Creek ambassadors at Tugaloo, bringing the Cherokees into conflict with the Lower Creeks. This became known as the Tugaloo Massacre during the Yamasee War in 1716. By 1717, Theophilus Hastings operated a trading center among the Creeks at Tugaloo.