Transient receptor potential cation channel, member A1

TRPA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J9P
Identifiers
Aliases	TRPA1, ANKTM1, FEPS, transient receptor potential cation channel subfamily A member 1
External IDs	OMIM: 604775 MGI: 3522699 HomoloGene: 7189 GeneCards: TRPA1
Gene location (Human) Chr. Chromosome 8 (human) Band No data available Start 72,019,917 bp End 72,075,617 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band No data available Start 14,872,648 bp End 14,918,862 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • channel activity • calcium-release channel activity • ion channel activity • temperature-gated cation channel activity • calcium channel activity Cellular component • stereocilium bundle • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane Biological process • response to organic cyclic compound • detection of chemical stimulus involved in sensory perception of pain • response to stimulus • ion transport • response to organic substance • cell surface receptor signaling pathway • response to pain • calcium ion transmembrane transport • response to cold • sensory perception of pain • protein homotetramerization • response to hydrogen peroxide • response to drug • thermoception • calcium ion transport • detection of mechanical stimulus involved in sensory perception of pain • release of sequestered calcium ion into cytosol • transmembrane transport • transport • ion transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8989	277328
Ensembl	ENSG00000104321	ENSMUSG00000032769
UniProt	O75762	Q8BLA8
RefSeq (mRNA)	NM_007332	NM_177781 NM_001348288
RefSeq (protein)	NP_015628	NP_808449 NP_001335217
Location (UCSC)	Chr 8: 72.02 – 72.08 Mb	Chr 8: 14.87 – 14.92 Mb
PubMed search

3J9P

8989

277328

ENSG00000104321

ENSMUSG00000032769

O75762

Q8BLA8

NM_007332

NM_177781
NM_001348288

NP_015628

NP_808449
NP_001335217

Transient receptor potential cation channel, subfamily A, member 1, also known as transient receptor potential ankyrin 1 or TRPA1, is a protein that in humans is encoded by the TRPA1 (and in other species by the Trpa1) gene.

TRPA1 is an ion channel located on the plasma membrane of many human and animal cells. This ion channel is best known as a sensor for environmental irritants giving rise to somatosensory modalities such as pain, cold and itch.

TRPA1 is a member of the transient receptor potential channel family. TRPA1 contains 14 N-terminal ankyrin repeats and is believed to function as a mechanical and chemical stress sensor. The specific function of this protein has not yet been determined; however, studies indicate that the function may involve a role in signal transduction and growth control.

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