Thyrotropin receptor

TSHR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XWT, 3G04
Identifiers
Aliases	TSHR, CHNG1, LGR3, hTSHR-I, thyroid stimulating hormone receptor, Thyrotropin receptor
External IDs	OMIM: 603372 MGI: 98849 HomoloGene: 315 GeneCards: TSHR
Gene ontology Molecular function • G-protein coupled peptide receptor activity • protein binding • G-protein coupled receptor activity • protein-hormone receptor activity • signal transducer activity • receptor activity • thyroid-stimulating hormone receptor activity • protein complex binding Cellular component • integral component of membrane • receptor complex • integral component of plasma membrane • membrane • cell surface • plasma membrane • basolateral plasma membrane Biological process • cell-cell signaling • G-protein coupled receptor signaling pathway • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • adenylate cyclase-activating G-protein coupled receptor signaling pathway • positive regulation of cell proliferation • activation of adenylate cyclase activity • hormone-mediated signaling pathway • signal transduction • nervous system development • cell surface receptor signaling pathway • positive regulation of cAMP biosynthetic process • thyroid-stimulating hormone signaling pathway • positive regulation of adenylate cyclase activity • cellular response to glycoprotein • cellular response to thyrotropin-releasing hormone Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7253	22095
Ensembl	ENSG00000165409	ENSMUSG00000020963
UniProt	P16473	P47750
RefSeq (mRNA)	NM_000369 NM_001018036 NM_001142626	NM_001113404 NM_011648
RefSeq (protein)	NP_000360 NP_001018046 NP_001136098	NP_035778.3 NP_001106875 NP_035778
Location (UCSC)	Chr 14: 80.95 – 81.15 Mb	Chr 12: 91.4 – 91.54 Mb
PubMed search

2XWT, 3G04

7253

22095

ENSG00000165409

ENSMUSG00000020963

P16473

P47750

NM_000369
NM_001018036
NM_001142626

NM_001113404
NM_011648

NP_000360
NP_001018046
NP_001136098

NP_035778.3
NP_001106875
NP_035778

The thyrotropin receptor (or TSH receptor) is a receptor (and associated protein) that responds to thyroid-stimulating hormone (also known as "thyrotropin") and stimulates the production of thyroxine (T4) and triiodothyronine (T3). The TSH receptor is a member of the G protein-coupled receptor superfamily of integral membrane proteins and is coupled to the G_s protein.

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Wikipedia