Thymosin beta-4

TMSB4X
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3TU5, 4PL7, 4PL8
Identifiers
Aliases	TMSB4X, FX, PTMB4, TB4X, TMSB4, thymosin beta 4, X-linked
External IDs	GeneCards: TMSB4X
Gene ontology Molecular function • actin binding • protein binding • RNA binding • actin monomer binding Cellular component • extracellular region • cytosol • cytoskeleton • platelet alpha granule lumen • nucleus • extracellular space • cytoplasm Biological process • platelet degranulation • regulation of cell migration • actin filament organization Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7114	n/a
Ensembl	ENSG00000205542	n/a
UniProt	P62328	n/a
RefSeq (mRNA)	NM_021109	n/a
RefSeq (protein)	NP_066932	n/a
Location (UCSC)	Chr X: 12.98 – 12.98 Mb	n/a
PubMed search		n/a

3TU5, 4PL7, 4PL8

7114

n/a

ENSG00000205542

n/a

P62328

n/a

NM_021109

n/a

NP_066932

n/a

Thymosin beta-4 is a protein that in humans is encoded by the TMSB4X gene.

The protein consists (in humans) of 43 amino acids and has a molecular weight of 4921 g/mol.

This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y (TMSB4Y).

It has been studied in a number of clinical trials.

The thymosin beta-4 peptide, if used after a heart attack, might reactivate cardiac progenitor cells to repair damaged heart tissue.

Thymosin beta-4 was allegedly used by some players in various Australian football codes and is under investigation by the Australian Sports Anti-Doping Authority for anti-doping violations.

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Wikipedia