Thromboxane receptor

TBXA2R
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1LBN
Identifiers
Aliases	TBXA2R, BDPLT13, TXA2-R, thromboxane A2 receptor
External IDs	OMIM: 188070 MGI: 98496 HomoloGene: 825 GeneCards: TBXA2R
Targeted by Drug
dinoprostone, dinoprost, U46619, ramatroban, terutroban
Gene ontology Molecular function • G-protein coupled receptor activity • thromboxane receptor activity • guanyl-nucleotide exchange factor activity • signal transducer activity • thromboxane A2 receptor activity • protein binding Cellular component • integral component of membrane • membrane • integral component of plasma membrane • acrosomal vesicle • plasma membrane • nuclear speck Biological process • G-protein coupled receptor signaling pathway • response to nutrient • positive regulation of angiogenesis • response to drug • signal transduction • positive regulation of GTPase activity • cellular response to lipopolysaccharide • positive regulation of blood pressure • response to ethanol • thromboxane A2 signaling pathway • positive regulation of blood coagulation • positive regulation of vasoconstriction • response to testosterone • positive regulation of cytosolic calcium ion concentration Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6915	21390
Ensembl	ENSG00000006638	ENSMUSG00000034881
UniProt	P21731	P30987
RefSeq (mRNA)	NM_001060 NM_201636	NM_001277265 NM_009325
RefSeq (protein)	NP_001051 NP_963998	NP_001264194.1 NP_033351.1 NP_001264194 NP_033351
Location (UCSC)	Chr 19: 3.59 – 3.61 Mb	Chr 10: 81.33 – 81.34 Mb
PubMed search

1LBN

6915

21390

ENSG00000006638

ENSMUSG00000034881

P21731

P30987

NM_001060
NM_201636

NM_001277265
NM_009325

NP_001051
NP_963998

NP_001264194.1
NP_033351.1
NP_001264194
NP_033351

The thromboxane receptor (TP) also known as the prostanoid TP receptor is a protein that in humans is encoded by the TBXA2R gene, The thromboxane receptor is one among the five classes of prostanoid receptors and was the first eicosanoid receptor cloned. The TP receptor derives its name from its preferred endogenous ligand thromboxane A₂.

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Wikipedia