Thiopurine methyltransferase
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| Aliases | TPMT, entrez:7172, TPMTD, thiopurine S-methyltransferase | ||||||||||||||||
| External IDs | OMIM: 187680 MGI: 98812 HomoloGene: 313 GeneCards: TPMT | ||||||||||||||||
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| Species | Human | Mouse | |||||||||||||||
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| Location (UCSC) | Chr 6: 18.13 – 18.16 Mb | Chr 13: 47.03 – 47.04 Mb | |||||||||||||||
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| thiopurine S-methyltransferase | |||||||||
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| Identifiers | |||||||||
| EC number | 2.1.1.67 | ||||||||
| CAS number | 67339-09-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
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| PMC | articles |
| PubMed | articles |
| NCBI | proteins |
NM_000367
NM_001346817
NM_001346818
NP_000358
NP_001333746
NP_001333747
Thiopurine methyltransferase or thiopurine S-methyltransferase (TPMT) is an enzyme that in humans is encoded by the TPMT gene. A pseudogene for this locus is located on chromosome 18q.
Thiopurine methyltransferase methylates thiopurine compounds. The methyl donor is S-adenosyl-L-methionine, which is converted to S-adenosyl-L-homocysteine. This enzyme metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct.
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