Thiazide-sensitive Na-Cl cotransporter

SLC12A3
Identifiers
Aliases	SLC12A3, NCC, NCCT, TSC, solute carrier family 12 member 3, Sodium-chloride symporter
External IDs	OMIM: 600968 MGI: 108114 HomoloGene: 287 GeneCards: SLC12A3
Targeted by Drug
chlorothiazide, cyclothiazide, hydrochlorothiazide, metolazone
Gene ontology Molecular function • cation:chloride symporter activity • protein binding • symporter activity • transporter activity • sodium:chloride symporter activity Cellular component • integral component of membrane • cytosol • plasma membrane • integral component of plasma membrane • extracellular exosome • apical plasma membrane • membrane Biological process • chloride transport • chloride transmembrane transport • ion transport • sodium ion transmembrane transport • transport • sodium ion transport • transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6559	20497
Ensembl	ENSG00000070915	ENSMUSG00000031766
UniProt	P55017	P59158
RefSeq (mRNA)	NM_000339 NM_001126107 NM_001126108	NM_001205311 NM_019415
RefSeq (protein)	NP_000330 NP_001119579 NP_001119580	NP_001192240.1 NP_001192240 NP_062288
Location (UCSC)	Chr 16: 56.87 – 56.92 Mb	Chr 8: 94.33 – 94.37 Mb
PubMed search

6559

20497

ENSG00000070915

ENSMUSG00000031766

P55017

P59158

NM_000339
NM_001126107
NM_001126108

NM_001205311
NM_019415

NP_000330
NP_001119579
NP_001119580

NP_001192240.1
NP_001192240
NP_062288

The sodium-chloride symporter (also known as Na⁺-Cl⁻ cotransporter, abbreviated as NCC or NCCT, or as the thiazide-sensitive Na⁺-Cl⁻cotransporter or TSC for short) is a cotransporter in the kidney which has the function of reabsorbing sodium and chloride ions from the tubular fluid into the cells of the distal convoluted tubule of the nephron. It is a member of the SLC12 cotransporter family of electroneutral cation-coupled chloride cotransporters. In humans, it is encoded by the gene SLC12A3 (solute carrier family 12 member 3) located in 16q13.

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Wikipedia