TSG-6

TNFAIP6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1O7B, 1O7C, 2PF5, 2WNO, 2N40
Identifiers
Aliases	TNFAIP6, TSG-6, TSG6, TNF alpha induced protein 6
External IDs	MGI: 1195266 HomoloGene: 5162 GeneCards: TNFAIP6
Gene location (Human) Chr. Chromosome 2 (human) Band 2q23.3 Start 151,357,592 bp End 151,380,048 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 C1.1 Start 52,038,009 bp End 52,056,686 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • hyaluronic acid binding • protein binding Cellular component • extracellular region • extracellular space • tertiary granule lumen • ficolin-1-rich granule lumen Biological process • cell-cell signaling • cell adhesion • inflammatory response • negative regulation of inflammatory response • signal transduction • positive regulation of cell migration • ovulation • neutrophil degranulation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7130	21930
Ensembl	ENSG00000123610	ENSMUSG00000053475
UniProt	P98066	O08859
RefSeq (mRNA)	NM_007115	NM_009398
RefSeq (protein)	NP_009046	NP_033424
Location (UCSC)	Chr 2: 151.36 – 151.38 Mb	Chr 2: 52.04 – 52.06 Mb
PubMed search

1O7B, 1O7C, 2PF5, 2WNO, 2N40

7130

21930

ENSG00000123610

ENSMUSG00000053475

P98066

O08859

NM_007115

NM_009398

NP_009046

NP_033424

Tumor necrosis factor-inducible gene 6 protein also known as TNF-stimulated gene 6 protein or TSG-6 is a protein that in humans is encoded by the TNFAIP6 (tumor necrosis factor, alpha-induced protein 6) gene.

TSG-6 is a 30 kDa secreted protein that contains a hyaluronan-binding LINK domain a and thus is a member of the hyaluronan-binding protein family, also called hyaladherins. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable, covalent complex with inter-alpha-inhibitor (IαI), and thus enhance the serine protease inhibitory activity of IαI, which is important in the protease network associated with inflammation. The expression of this gene can be induced by a number of signalling molecules, principally tumor necrosis factor α (TNF-α) and interleukin-1 (IL-1). The expression can also be induced by mechanical stimuli in vascular smooth muscle cells, and is found to be correlated with proteoglycan synthesis and aggregation. TSG-6 has been shown to modulate macrophage plasticity and signal the transition of LPS-treated macrophages from pro- to anti-inflammatory phenotype.

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Wikipedia