TRPM5

TRPM5
Identifiers
Aliases	TRPM5, LTRPC5, MTR1, transient receptor potential cation channel subfamily M member 5
External IDs	OMIM: 604600 MGI: 1861718 HomoloGene: 22818 GeneCards: TRPM5
Targeted by Drug
flufenamic acid, hydron, spermine, steviol, Rebaudioside A, stevioside
Gene ontology Molecular function • voltage-gated ion channel activity • ion channel activity • potassium channel activity • calcium activated cation channel activity • sodium channel activity Cellular component • plasma membrane • membrane • neuronal cell body • dendrite • integral component of membrane Biological process • ion transport • sodium ion transmembrane transport • sensory perception of taste • calcium ion transmembrane transport • potassium ion transmembrane transport • transport • cation transport • regulation of ion transmembrane transport • ion transmembrane transport • transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	29850	56843
Ensembl	ENSG00000070985	ENSMUSG00000009246
UniProt	Q9NZQ8	Q9JJH7
RefSeq (mRNA)	NM_014555	NM_020277
RefSeq (protein)	NP_055370	NP_064673.2 NP_064673
Location (UCSC)	Chr 11: 2.4 – 2.42 Mb	Chr 7: 143.07 – 143.09 Mb
PubMed search

29850

56843

ENSG00000070985

ENSMUSG00000009246

Q9NZQ8

Q9JJH7

NM_014555

NM_020277

NP_055370

NP_064673.2
NP_064673

Transient receptor potential cation channel subfamily M member 5 (TRPM5), also known as long transient receptor potential channel 5 is a protein that in humans is encoded by the TRPM5 gene.

TRPM5 is a calcium-activated non-selective cation channel that induces depolarization upon increases in intracellular calcium, it is a signal mediator in chemosensory cells. Channel activity is initiated by a rise in the intracellular calcium, and the channel permeates monovalent cations as K⁺ and Na⁺. TRPM5 is a key component of taste transduction in the gustatory system of bitter, sweet and umami tastes being activated by high levels of intracellular calcium. It has also been targeted as a possible contributor to fat taste signaling. The calcium dependent opening of TRPM5 produces a depolarizing generator potential which leads to an action potential.

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Wikipedia