TRPM3

TRPM3
Identifiers
Aliases	TRPM3, GON-2, LTRPC3, MLSN2, transient receptor potential cation channel subfamily M member 3
External IDs	MGI: 2443101 HomoloGene: 62287 GeneCards: TRPM3
Targeted by Drug
NN-dimethyl-D-erythrosphingosine, nifedipine, pregnenolone sulfate, mefenamic acid, , pioglitazone, rosiglitazone, Troglitazone, 2-aminoethoxydiphenylborate
Gene ontology Molecular function • ion channel activity • calcium activated cation channel activity • cation channel activity • calcium channel activity Cellular component • integral component of membrane • plasma membrane • membrane Biological process • detection of temperature stimulus • ion transport • protein tetramerization • sensory perception of temperature stimulus • calcium ion transport • transport • ion transmembrane transport • cation transport • transmembrane transport • calcium ion transmembrane transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	80036	226025
Ensembl	ENSG00000083067	ENSMUSG00000052387
UniProt	Q9HCF6	n/a
RefSeq (mRNA)	NM_001007470 NM_001007471 NM_020952 NM_024971 NM_206944 NM_206945 NM_206946 NM_206947 NM_206948	NM_001035239 NM_001035240 NM_001035241 NM_001035242 NM_001035243 NM_001035244 NM_001035245 NM_001035246 NM_177341
RefSeq (protein)	NP_001007471 NP_001007472 NP_066003 NP_079247 NP_996827 NP_996828 NP_996829 NP_996830 NP_996831	n/a
Location (UCSC)	Chr 9: 70.53 – 71.45 Mb	Chr 19: 22.14 – 22.99 Mb
PubMed search

80036

226025

ENSG00000083067

ENSMUSG00000052387

Q9HCF6

n/a

NM_206945
NM_206946
NM_206947
NM_206948

NM_001035244
NM_001035245
NM_001035246
NM_177341

NP_996828
NP_996829
NP_996830
NP_996831

n/a

Transient receptor potential cation channel subfamily M member 3 is a protein that in humans is encoded by the TRPM3 gene.

The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been -identified. TRPM3 was shown to be activated by the neurosteroid pregnenolone sulphate in pancreatic beta cell. The activation causes calcium influx and subsequent insulin release, therefore it is suggested that TRPM3 modulates glucose homeostasis.

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Wikipedia