TRPC6

Identifiers

TRPC6, FSGS2, TRP6, transient receptor potential cation channel subfamily C member 6

External IDs

Gene ontology
Molecular function	• actinin binding • store-operated calcium channel activity • ATPase binding • clathrin binding • inositol 1,4,5 trisphosphate binding • ion channel activity • protein binding • cation channel activity • actin binding • calcium channel activity
Cellular component	• cytoplasm • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • slit diaphragm
Biological process	• regulation of cytosolic calcium ion concentration • positive regulation of cytosolic calcium ion concentration • aging • cation transport • ion transport • single fertilization • platelet activation • positive regulation of ion transmembrane transporter activity • negative regulation of dendrite morphogenesis • positive regulation of peptidyl-threonine phosphorylation • calcium ion transmembrane transport • positive regulation of neuron differentiation • neuron differentiation • transport • manganese ion transport • cellular response to hypoxia • calcium ion transport • cellular response to hydrogen peroxide • positive regulation of calcium ion transport • transmembrane transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


7225


22068


ENSG00000137672


ENSMUSG00000031997


Q9Y210


Q61143

RefSeq (mRNA)


NM_004621


NM_001282086 NM_001282087 NM_013838

RefSeq (protein)


NP_004612


NP_038866.2 NP_001269015 NP_001269016 NP_038866

Location (UCSC)

PubMed search

Transient receptor potential cation channel, subfamily C, member 6, also known as TRPC6, is a human gene encoding a protein of the same name. TRPC6 is a transient receptor potential ion channel. It has been associated with depression and anxiety (see below), as well as with focal segmental glomerulosclerosis (FSGS).