TRADD

TRADD
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1F2H, 1F3V
Identifiers
Aliases	TRADD, Hs.89862, TNFRSF1A associated via death domain
External IDs	OMIM: 603500 MGI: 109200 HomoloGene: 2807 GeneCards: TRADD
Gene ontology Molecular function • death domain binding • protein complex binding • signal transducer activity • kinase binding • protein binding • identical protein binding • binding, bridging • tumor necrosis factor receptor binding Cellular component • cytoplasm • cytosol • receptor complex • plasma membrane • protein complex • death-inducing signaling complex • membrane raft • cytoskeleton • nucleus Biological process • extrinsic apoptotic signaling pathway • protein heterooligomerization • activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway • positive regulation of hair follicle development • regulation of tumor necrosis factor-mediated signaling pathway • tumor necrosis factor-mediated signaling pathway • death-inducing signaling complex assembly • positive regulation of NF-kappaB transcription factor activity • positive regulation of apoptotic process • positive regulation of I-kappaB kinase/NF-kappaB signaling • regulation of extrinsic apoptotic signaling pathway via death domain receptors • I-kappaB kinase/NF-kappaB signaling • activation of cysteine-type endopeptidase activity involved in apoptotic process • extrinsic apoptotic signaling pathway via death domain receptors • signal transduction • apoptotic process • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • regulation of necroptotic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8717	71609
Ensembl	ENSG00000102871	ENSMUSG00000031887
UniProt	Q15628	Q3U0V2
RefSeq (mRNA)	NM_003789 NM_153425 NM_001323552	NM_001033161
RefSeq (protein)	NP_001310481 NP_003780	NP_001028333.1 NP_001028333
Location (UCSC)	Chr 16: 67.15 – 67.16 Mb	Chr 8: 105.26 – 105.26 Mb
PubMed search

1F2H, 1F3V

8717

71609

ENSG00000102871

ENSMUSG00000031887

Q15628

Q3U0V2

NM_003789
NM_153425
NM_001323552

NM_001033161

NP_001310481
NP_003780

NP_001028333.1
NP_001028333

Tumor necrosis factor receptor type 1-associated DEATH domain protein is a protein that in humans is encoded by the TRADD gene.

TRADD is an adaptor protein.

The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway.

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Wikipedia