TPCN2

TPCN2
Identifiers
Aliases	TPCN2, SHEP10, TPC2, two pore segment channel 2
External IDs	MGI: 2385297 HomoloGene: 16375 GeneCards: TPCN2
Targeted by Drug
phosphatidyl (3,5) inositol biphosphate, verapamil
Gene ontology Molecular function • calcium channel activity • voltage-gated ion channel activity • ion channel activity • protein binding • identical protein binding • protein kinase binding • NAADP-sensitive calcium-release channel activity • voltage-gated calcium channel activity Cellular component • integral component of membrane • membrane • plasma membrane • endosome membrane • lysosome • lysosomal membrane Biological process • release of sequestered calcium ion into cytosol • membrane depolarization during action potential • response to vitamin D • regulation of ion transmembrane transport • cellular calcium ion homeostasis • ion transport • ion transmembrane transport • regulation of autophagy • calcium ion transmembrane transport • transport • lysosome organization • calcium-mediated signaling • calcium ion transport • transmembrane transport • smooth muscle contraction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	219931	233979
Ensembl	ENSG00000162341	ENSMUSG00000048677
UniProt	Q8NHX9	Q8BWC0
RefSeq (mRNA)	NM_139075	NM_146206
RefSeq (protein)	NP_620714	NP_666318.2 NP_666318
Location (UCSC)	Chr 11: 69.05 – 69.16 Mb	Chr 7: 145.19 – 145.28 Mb
PubMed search

219931

233979

ENSG00000162341

ENSMUSG00000048677

Q8NHX9

Q8BWC0

NM_139075

NM_146206

NP_620714

NP_666318.2
NP_666318

Two pore segment channel 2 (TPC2) is a human protein encoded by the TPCN2 is a protein which in humans is encoded by the TPCN2 gene. TPC2 is an ion channel, however, in contrast to other calcium and sodium channels which have four homologous domains, each containing 6 transmembrane segments (S1 to S6), TPCN1 only contains two domain (each containing segments S1 to S6).

TPC2 is homologous to TPC1, the best characterized member of the TPC family. The structure of a TPC1 ortholog from Arabidopsis thaliana has been solved by two laboratories. The structures were solved using X-ray crystallography and contained the fold of a voltage-gated ion channel and EF hands.

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Wikipedia