TGFβ3

TGFB3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1KTZ, 1TGJ, 1TGK, 2PJY, 3EO1, 4UM9
Identifiers
Aliases	TGFB3, ARVD, ARVD1, RNHF, TGF-beta3, Transforming growth factor, beta 3, LDS5, transforming growth factor beta 3
External IDs	MGI: 98727 HomoloGene: 2433 GeneCards: TGFB3
Gene ontology Molecular function • type III transforming growth factor beta receptor binding • cytokine activity • type I transforming growth factor beta receptor binding • protein binding • identical protein binding • protein heterodimerization activity • transforming growth factor beta receptor binding • growth factor activity • transforming growth factor beta binding • type II transforming growth factor beta receptor binding Cellular component • cytoplasm • extracellular matrix • T-tubule • plasma membrane • secretory granule • cell surface • neuronal cell body • platelet alpha granule lumen • nucleus • extracellular region • extracellular space • intracellular membrane-bounded organelle Biological process • regulation of apoptotic process • negative regulation of neuron apoptotic process • positive regulation of collagen biosynthetic process • palate development • cell-cell junction organization • regulation of MAPK cascade • SMAD protein signal transduction • SMAD protein import into nucleus • positive regulation of bone mineralization • embryonic neurocranium morphogenesis • response to progesterone • female pregnancy • response to laminar fluid shear stress • aging • platelet degranulation • negative regulation of DNA replication • in utero embryonic development • negative regulation of transforming growth factor beta receptor signaling pathway • wound healing • salivary gland morphogenesis • mammary gland development • odontogenesis • response to estrogen • positive regulation of DNA replication • cell growth • activation of MAPK activity • positive regulation of protein secretion • ossification involved in bone remodeling • uterine wall breakdown • frontal suture morphogenesis • inner ear development • negative regulation of macrophage cytokine production • lung alveolus development • digestive tract development • transforming growth factor beta receptor signaling pathway • positive regulation of filopodium assembly • positive regulation of cell division • face morphogenesis • detection of hypoxia • positive regulation of transcription from RNA polymerase II promoter • positive regulation of SMAD protein import into nucleus • positive regulation of occluding junction disassembly • negative regulation of cell proliferation • positive regulation of epithelial to mesenchymal transition • positive regulation of stress fiber assembly • regulation of epithelial to mesenchymal transition involved in endocardial cushion formation • positive regulation of apoptotic process • response to hypoxia • positive regulation of pathway-restricted SMAD protein phosphorylation • positive regulation of transcription, DNA-templated • negative regulation of vascular smooth muscle cell proliferation • BMP signaling pathway • cell development Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7043	21809
Ensembl	ENSG00000119699	ENSMUSG00000021253
UniProt	P10600	P17125
RefSeq (mRNA)	NM_003239 NM_001329938 NM_001329939	NM_009368
RefSeq (protein)	NP_001316867 NP_001316868 NP_003230	n/a
Location (UCSC)	Chr 14: 75.96 – 75.98 Mb	Chr 12: 86.06 – 86.08 Mb
PubMed search

1KTZ, 1TGJ, 1TGK, 2PJY, 3EO1, 4UM9

7043

21809

ENSG00000119699

ENSMUSG00000021253

P10600

P17125

NM_003239
NM_001329938
NM_001329939

NM_009368

NP_001316867
NP_001316868
NP_003230

n/a

Transforming growth factor beta-3 is a protein that in humans is encoded by the TGFB3 gene.

It is a type of protein, known as a cytokine, which is involved in cell differentiation, embryogenesis and development. It belongs to a large family of cytokines called the Transforming growth factor beta superfamily, which includes the TGF-β family, Bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs), inhibins and activins.

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Wikipedia