TFR2

TFR2
Identifiers
Aliases	TFR2, HFE3, TFRC2, transferrin receptor 2
External IDs	MGI: 1354956 HomoloGene: 2428 GeneCards: TFR2
Gene ontology Molecular function • transferrin receptor activity • co-receptor binding • protein binding • glycoprotein binding Cellular component • cytoplasm • integral component of membrane • integral component of plasma membrane • membrane • plasma membrane • cytoplasmic vesicle • HFE-transferrin receptor complex • external side of plasma membrane Biological process • positive regulation of endocytosis • receptor-mediated endocytosis • iron ion transport • transferrin transport • positive regulation of peptide hormone secretion • cellular response to iron ion • ferrous iron import into cell • response to iron ion • positive regulation of transcription from RNA polymerase II promoter • cellular iron ion homeostasis • positive regulation of protein maturation • iron ion homeostasis • acute-phase response Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7036	50765
Ensembl	ENSG00000106327	ENSMUSG00000029716
UniProt	Q9UP52	Q9JKX3
RefSeq (mRNA)	NM_001206855 NM_003227	NM_001289507 NM_001289509 NM_001289511 NM_015799
RefSeq (protein)	NP_001193784 NP_003218	NP_001276436.1 NP_001276438.1 NP_001276440.1 NP_056614.3 NP_001276436 NP_001276438 NP_001276440 NP_056614
Location (UCSC)	Chr 7: 100.62 – 100.64 Mb	Chr 5: 137.57 – 137.59 Mb
PubMed search

7036

50765

ENSG00000106327

ENSMUSG00000029716

Q9UP52

Q9JKX3

NM_001206855
NM_003227

NM_001289507
NM_001289509
NM_001289511
NM_015799

NP_001193784
NP_003218

NP_001276438
NP_001276440
NP_056614

Transferrin receptor 2 (TfR2) is a protein that in humans is encoded by the TFR2 gene. This protein is involved in the uptake of transferrin-bound iron into cells by endocytosis, although its role is minor compared to transferrin receptor 1.

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Wikipedia