TET1

TET1
Identifiers
Aliases	TET1, CXXC6, LCX, bA119F7.1, MLL-TET1-MLL, Tet methylcytosine dioxygenase 1
External IDs	MGI: 1098693 HomoloGene: 12735 GeneCards: TET1
Gene ontology Molecular function • iron ion binding • zinc ion binding • methylcytosine dioxygenase activity • dioxygenase activity • metal ion binding • oxidoreductase activity • DNA binding Cellular component • nucleus Biological process • regulation of transcription, DNA-templated • positive regulation of histone methylation • protein O-linked glycosylation • negative regulation of methylation-dependent chromatin silencing • transcription, DNA-templated • stem cell population maintenance • inner cell mass cell differentiation • positive regulation of cell proliferation • DNA demethylation • oxidation-reduction process • covalent chromatin modification • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	80312	52463
Ensembl	ENSG00000138336	ENSMUSG00000047146
UniProt	Q8NFU7	Q3URK3
RefSeq (mRNA)	NM_030625	NM_001253857 NM_027384
RefSeq (protein)	NP_085128	NP_001240786 NP_081660
Location (UCSC)	Chr 10: 68.56 – 68.69 Mb	Chr 10: 62.8 – 62.91 Mb
PubMed search

80312

52463

ENSG00000138336

ENSMUSG00000047146

Q8NFU7

Q3URK3

NM_030625

NM_001253857
NM_027384

NP_085128

NP_001240786
NP_081660

Ten-eleven translocation methylcytosine dioxygenase 1 (TET1) is a member of the TET family of enzymes that in humans is encoded by the TET1 gene.

TET1 was first discovered in a 61-year-old patient with a rare variation of t(10;11)(q22;q23) acute myeloid leukemia(AML) as a zinc-finger binding protein (specifically on the CXXC domain) that fuses to the gene MLL. Another study confirmed that this protein was a translocation partner of MLL in an 8-year-old patient with t(10;11)(q22;q23) AML and named the protein Ten-Eleven Translocation 1.

TET1 catalyzes the conversion of the modified DNA base 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC). TET1 produces 5-hmC by oxidation of 5-mC in an iron and alpha-ketoglutarate dependent manner. The conversion of 5-mC to 5-hmC has been proposed as the initial step of active DNA demethylation in mammals. Additionally, downgrading TET1 has decreased levels of 5-formylcytosine (5-fC) and 5-carboxylcytosine (5-caC) in both cell cultures and mice.

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