KMT2A

KMT2A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2AGH, 2J2S, 2JYI, 2KKF, 2KU7, 2KYU, 2LXS, 2LXT, 2MTN, 2W5Y, 2W5Z, 3EG6, 3EMH, 3LQI, 3LQJ, 3P4F, 3U85, 3U88, 4ESG, 4GQ6, 4NW3, 5F6L, 5F5E
Identifiers
Aliases	KMT2A, ALL-1, CXXC7, HRX, HTRX1, MLL, MLL/GAS7, MLL1, MLL1A, TET1-MLL, TRX1, WDSTS, MLL-AF9, lysine methyltransferase 2A, Histone-lysine N-methyltransferase HRX
External IDs	MGI: 96995 HomoloGene: 4338 GeneCards: KMT2A
Gene ontology Molecular function • methyltransferase activity • transferase activity • DNA binding • protein homodimerization activity • AT DNA binding • transcription factor activity, sequence-specific DNA binding • zinc ion binding • chromatin binding • metal ion binding • core promoter sequence-specific DNA binding • protein binding • unmethylated CpG binding • lysine-acetylated histone binding • identical protein binding • transcription regulatory region DNA binding • histone-lysine N-methyltransferase activity • histone methyltransferase activity (H3-K4 specific) Cellular component • nucleoplasm • MLL1 complex • nucleus • histone methyltransferase complex • cytosol Biological process • visual learning • response to potassium ion • regulation of transcription, DNA-templated • cognition • positive regulation of transporter activity • positive regulation of cellular response to drug • response to light stimulus • protein complex assembly • rhythmic process • regulation of short-term neuronal synaptic plasticity • histone H3-K4 trimethylation • membrane depolarization • regulation of histone H3-K4 methylation • regulation of histone H3-K9 acetylation • transcription from RNA polymerase II promoter • post-embryonic development • peptidyl-lysine monomethylation • spleen development • circadian regulation of gene expression • regulation of histone H3-K14 acetylation • transcription, DNA-templated • regulation of histone H3-K27 acetylation • positive regulation of transcription, DNA-templated • DNA methylation • histone H3-K4 methylation • methylation • positive regulation of histone H3-K4 methylation • exploration behavior • embryonic hemopoiesis • histone H3-K4 dimethylation • regulation of gene expression • homeostasis of number of cells within a tissue • histone H4-K16 acetylation • definitive hemopoiesis • anterior/posterior pattern specification • negative regulation of cell proliferation • positive regulation of transcription from RNA polymerase II promoter • apoptotic process • covalent chromatin modification • regulation of megakaryocyte differentiation • regulation of hematopoietic stem cell differentiation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4297	214162
Ensembl	ENSG00000118058	ENSMUSG00000002028
UniProt	Q03164	P55200
RefSeq (mRNA)	NM_001197104 NM_005933 NM_024891	NM_001081049
RefSeq (protein)	NP_001184033 NP_005924	NP_001074518
Location (UCSC)	Chr 11: 118.44 – 118.53 Mb	Chr 9: 44.8 – 44.88 Mb
PubMed search

2AGH, 2J2S, 2JYI, 2KKF, 2KU7, 2KYU, 2LXS, 2LXT, 2MTN, 2W5Y, 2W5Z, 3EG6, 3EMH, 3LQI, 3LQJ, 3P4F, 3U85, 3U88, 4ESG, 4GQ6, 4NW3, 5F6L, 5F5E

4297

214162

ENSG00000118058

...
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