TECTA

TECTA
Identifiers
Aliases	TECTA, DFNA12, DFNA8, DFNB21, tectorin alpha
External IDs	MGI: 109575 HomoloGene: 3955 GeneCards: TECTA
Gene ontology Molecular function • extracellular matrix structural constituent Cellular component • proteinaceous extracellular matrix • anchored component of membrane • extracellular exosome • membrane • extracellular region • plasma membrane Biological process • cell-matrix adhesion • sensory perception of sound • C-terminal protein lipidation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7007	21683
Ensembl	ENSG00000109927	ENSMUSG00000037705
UniProt	O75443	O08523
RefSeq (mRNA)	NM_005422	NM_009347 NM_001324548
RefSeq (protein)	NP_005413	NP_033373.2 NP_001311477 NP_033373
Location (UCSC)	Chr 11: 121.1 – 121.19 Mb	Chr 9: 42.33 – 42.4 Mb
PubMed search

7007

21683

ENSG00000109927

ENSMUSG00000037705

O75443

O08523

NM_005422

NM_009347
NM_001324548

NP_005413

NP_033373.2
NP_001311477
NP_033373

Alpha-tectorin is a protein that in humans is encoded by the TECTA gene.

The tectorial membrane is an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Alpha-tectorin is one of the major noncollagenous components of the tectorial membrane. Mutations in the TECTA gene have been shown to be responsible for autosomal dominant nonsyndromic hearing impairment and a recessive form of sensorineural pre-lingual non-syndromic deafness.

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Wikipedia