TBCD

TBCD
Identifiers
Aliases	TBCD, SSD-1, tfcD, tubulin folding cofactor D, PEBAT
External IDs	MGI: 1919686 HomoloGene: 4368 GeneCards: TBCD
Gene location (Human) Chr. Chromosome 17 (human) Band 17q25.3 Start 82,752,064 bp End 82,945,922 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 E2 Start 121,451,949 bp End 121,617,164 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • chaperone binding • GTPase activator activity • protein binding • beta-tubulin binding Cellular component • cytoplasm • lateral plasma membrane • membrane • bicellular tight junction • adherens junction • plasma membrane • cell junction • microtubule • centrosome • microtubule organizing center • cytoskeleton Biological process • negative regulation of cell-substrate adhesion • negative regulation of microtubule polymerization • adherens junction assembly • protein folding • bicellular tight junction assembly • positive regulation of GTPase activity • post-chaperonin tubulin folding pathway • mitotic cell cycle • cell morphogenesis involved in neuron differentiation • tubulin complex assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6904	108903
Ensembl	ENSG00000278759 ENSG00000141556	ENSMUSG00000039230
UniProt	Q9BTW9	Q8BYA0
RefSeq (mRNA)	NM_001033052 NM_005993	NM_029878
RefSeq (protein)	NP_005984	NP_084154
Location (UCSC)	Chr 17: 82.75 – 82.95 Mb	Chr 17: 121.45 – 121.62 Mb
PubMed search

6904

108903

ENSG00000278759
ENSG00000141556

ENSMUSG00000039230

Q9BTW9

Q8BYA0

NM_001033052
NM_005993

NM_029878

NP_005984

NP_084154

Tubulin-specific chaperone D is a protein that in humans is encoded by the TBCD gene.

Cofactor D is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state.

TBCD has been shown to interact with ARL2.

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Wikipedia