TAP2

TAP2
Identifiers
Aliases	TAP2, ABC18, ABCB3, APT2, D6S217E, PSF-2, PSF2, RING11, transporter 2, ATP-binding cassette, sub-family B (MDR/TAP), transporter 2, ATP binding cassette subfamily B member
External IDs	MGI: 98484 HomoloGene: 37323 GeneCards: TAP2
Gene ontology Molecular function • MHC protein binding • ATPase activity, coupled to transmembrane movement of substances • nucleotide binding • peptide-transporting ATPase activity • transporter activity • tapasin binding • MHC class Ib protein binding • peptide antigen-transporting ATPase activity • ATPase activity • protein binding • TAP1 binding • ATP binding • peptide transporter activity Cellular component • TAP complex • endoplasmic reticulum membrane • membrane • integral component of endoplasmic reticulum membrane • integral component of membrane • endoplasmic reticulum • nuclear speck • phagocytic vesicle membrane • endoplasmic reticulum-Golgi intermediate compartment membrane Biological process • adaptive immune response • immune system process • antigen processing and presentation of peptide antigen via MHC class I • antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent • transmembrane transport • protein transport • peptide transport • viral process • cytosol to ER transport • antigen processing and presentation of endogenous peptide antigen via MHC class I • peptide antigen transport • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane • transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6891	21355
Ensembl	ENSG00000204267 ENSG00000206299 ENSG00000228582 ENSG00000206235 ENSG00000225967 ENSG00000237599 ENSG00000223481 ENSG00000232326	ENSMUSG00000024339
UniProt	Q03519	P36371
RefSeq (mRNA)	NM_018833 NM_000544 NM_001290043	NM_011530
RefSeq (protein)	NP_000535 NP_001276972 NP_061313	NP_035660
Location (UCSC)	Chr 6: 32.82 – 32.84 Mb	Chr 17: 34.2 – 34.22 Mb
PubMed search

6891

21355

ENSG00000237599
ENSG00000223481
ENSG00000232326

ENSMUSG00000024339

Q03519

P36371

NM_018833
NM_000544
NM_001290043

NM_011530

NP_000535
NP_001276972
NP_061313

NP_035660

TAP2 is a gene in humans that encodes the protein Antigen peptide transporter 2.

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2 (TAP1). The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, schizophrenia, and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.

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Wikipedia