TAP1

TAP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JJ7
Identifiers
Aliases	TAP1, ABC17, ABCB2, APT1, D6S114E, PSF-1, PSF1, RING4, TAP1*0102N, TAP1N, transporter 1, ATP-binding cassette, sub-family B (MDR/TAP), transporter 1, ATP binding cassette subfamily B member
External IDs	MGI: 98483 HomoloGene: 495 GeneCards: TAP1
Gene ontology Molecular function • MHC protein binding • nucleotide binding • protein homodimerization activity • peptide-transporting ATPase activity • peptide transporter activity • TAP2 binding • MHC class Ib protein binding • ATPase activity • protein binding • MHC class I protein binding • TAP1 binding • ATP binding • peptide antigen binding • ADP binding • ATPase activity, coupled to transmembrane movement of substances Cellular component • integral component of membrane • endoplasmic reticulum membrane • membrane • TAP complex • integral component of endoplasmic reticulum membrane • mitochondrion • endoplasmic reticulum • microtubule organizing center • phagocytic vesicle membrane • endoplasmic reticulum-Golgi intermediate compartment membrane Biological process • defense response • adaptive immune response • immune system process • antigen processing and presentation of peptide antigen via MHC class I • antigen processing and presentation of endogenous peptide antigen via MHC class I • transport • protein transport • peptide transport • viral process • cytosol to ER transport • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane • transmembrane transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6890	21354
Ensembl	n/a	ENSMUSG00000037321
UniProt	Q03518	P21958
RefSeq (mRNA)	NM_001292022 NM_000593	NM_001161730 NM_013683
RefSeq (protein)	NP_000584 NP_001278951	NP_038711.2 NP_001155202 NP_038711
Location (UCSC)	Chr 6: 32.85 – 32.85 Mb	Chr 17: 34.19 – 34.2 Mb
PubMed search

1JJ7

6890

21354

n/a

ENSMUSG00000037321

Q03518

P21958

NM_001292022
NM_000593

NM_001161730
NM_013683

NP_000584
NP_001278951

NP_038711.2
NP_001155202
NP_038711

Transporter associated with Antigen Processing 1 is a protein that in humans is encoded by the TAP1 gene.

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease.

...
Wikipedia