TACSTD2

TACSTD2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MAE, 2MVK, 2MVL
Identifiers
Aliases	TACSTD2, EGP-1, EGP1, GA733-1, GA7331, GP50, M1S1, TROP2, tumor-associated calcium signal transducer 2, tumor associated calcium signal transducer 2
External IDs	MGI: 1861606 HomoloGene: 1763 GeneCards: TACSTD2
Gene ontology Molecular function • protein binding • receptor activity Cellular component • integral component of membrane • cytosol • lateral plasma membrane • membrane • plasma membrane • integral component of plasma membrane • basal plasma membrane • extracellular exosome • nucleus • extracellular space Biological process • ureteric bud morphogenesis • response to stimulus • negative regulation of ruffle assembly • negative regulation of cell motility • cell surface receptor signaling pathway • negative regulation of branching involved in ureteric bud morphogenesis • cell proliferation • regulation of epithelial cell proliferation • negative regulation of stress fiber assembly • negative regulation of substrate adhesion-dependent cell spreading • negative regulation of epithelial cell migration • visual perception • cell-cell adhesion • positive regulation of stem cell differentiation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4070	56753
Ensembl	ENSG00000184292	ENSMUSG00000051397
UniProt	P09758	Q8BGV3
RefSeq (mRNA)	NM_002353	NM_020047
RefSeq (protein)	NP_002344	NP_064431
Location (UCSC)	Chr 1: 58.58 – 58.58 Mb	Chr 6: 67.53 – 67.54 Mb
PubMed search

2MAE, 2MVK, 2MVL

4070

56753

ENSG00000184292

ENSMUSG00000051397

P09758

Q8BGV3

NM_002353

NM_020047

NP_002344

NP_064431

Tumor-associated calcium signal transducer 2, also known as Trop-2 and as epithelial glycoprotein-1 antigen (EGP-1), is a protein that in humans is encoded by the TACSTD2 gene.

This intronless gene encodes a carcinoma-associated antigen defined by the monoclonal antibody GA733. This antigen is a member of a family including at least two type I membrane proteins. It transduces an intracellular calcium signal and acts as a cell surface receptor.

Mutations of this gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness.

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Wikipedia