Synaptic vesicle glycoprotein 2A

SV2A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4V11
Identifiers
Aliases	SV2A, SV2, synaptic vesicle glycoprotein 2A
External IDs	MGI: 1927139 HomoloGene: 32237 GeneCards: SV2A
Gene location (Human) Chr. Chromosome 1 (human) Band 1q21.2 Start 149,903,318 bp End 149,917,882 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 F2.1 Start 96,181,151 bp End 96,195,521 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • transmembrane transporter activity • transporter activity • protein kinase binding • receptor activity Cellular component • membrane • synaptic vesicle • cell-cell junction • neuromuscular junction • plasma membrane • synapse • presynaptic active zone • terminal bouton • cell junction • endoplasmic reticulum • cytoplasmic vesicle • integral component of membrane • integral component of synaptic vesicle membrane • synaptic vesicle membrane • neuron projection • dendrite • neuronal cell body Biological process • cellular calcium ion homeostasis • transmembrane transport • neurotransmitter transport • regulation of gamma-aminobutyric acid secretion • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9900	64051
Ensembl	ENSG00000159164	ENSMUSG00000038486
UniProt	Q7L0J3	Q9JIS5
RefSeq (mRNA)	NM_014849 NM_001278719 NM_001328674 NM_001328675	NM_022030
RefSeq (protein)	NP_001265648 NP_001315603 NP_001315604 NP_055664	NP_071313
Location (UCSC)	Chr 1: 149.9 – 149.92 Mb	Chr 1: 96.18 – 96.2 Mb
PubMed search

4V11

9900

64051

ENSG00000159164

ENSMUSG00000038486

Q7L0J3

Q9JIS5

NM_014849
NM_001278719
NM_001328674
NM_001328675

NM_022030

NP_001265648
NP_001315603
NP_001315604
NP_055664

NP_071313

Synaptic vesicle glycoprotein 2A is a ubiquitous synaptic vesicle protein that in humans is encoded by the SV2A gene. The protein is targeted by the anti-epileptic drugs (anticonvulsants) levetiracetam and brivaracetam. but not the chemically similar drug etiracetam

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