Sulfhemoglobin
| Sulfhemoglobinemia | |
|---|---|
| Classification and external resources | |
| Specialty | hematology |
| ICD-10 | D74.8 |
| ICD-9-CM | 289.7 |
| MedlinePlus | 003371 |
| MeSH | D013436 |
Sulfhemoglobinemia (or sulfhaemoglobinaemia) is a rare condition in which there is excess sulfhemoglobin (SulfHb) in the blood. The pigment is a greenish derivative of hemoglobin which cannot be converted back to normal, functional hemoglobin. It causes cyanosis even at low blood levels.
It is a rare blood condition that occurs when a sulfur atom is incorporated into the hemoglobin molecule. When hydrogen sulfide (H2S) (or sulfide ions) and ferric ions combine in the blood, the blood is incapable of carrying oxygen.
This can be caused by taking medications that contain sulfonamides under certain conditions (i.e., overdosing of sumatriptan).
Sulfhemoglobinemia is usually drug induced. Drugs associated with sulfhemoglobinemia include sulphonamides and sulfasalazine. Another possible cause is occupational exposure to sulfur compounds.
It can be caused by phenazopyridine.
The condition generally resolves itself with erythrocyte (red blood cell) turnover, although blood transfusions can be necessary in extreme cases.
Symptoms include a blueish or greenish discoloration of the blood, skin, and mucous membranes, even though a blood count test may not show any abnormalities in the blood. This discoloration is called cyanosis, and is caused by greater than 5 grams per cent of deoxyhemaglobinemia, or 1.5 grams per cent of methemaglobinemia, or 0.5 grams per cent of sulphemaglobinemia, all serious medical abnormalities.
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