Stem cell factor

KITLG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1EXZ, 1SCF, 2E9W
Identifiers
Aliases	KITLG, FPH2, FPHH, KL-1, Kitl, MGF, SCF, SF, SHEP7, DCUA, KIT ligand, DFNA69
External IDs	OMIM: 184745 MGI: 96974 HomoloGene: 692 GeneCards: KITLG
Genetically Related Diseases
, testicular cancer
Gene ontology Molecular function • cytokine activity • stem cell factor receptor binding • protein binding • growth factor activity • Ras guanyl-nucleotide exchange factor activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity Cellular component • integral component of membrane • membrane • • extracellular region • cytoskeleton • cell projection • filopodium • lamellipodium • cytoplasm • plasma membrane Biological process • male gonad development • positive regulation of MAP kinase activity • positive regulation of melanocyte differentiation • positive regulation of leukocyte migration • positive regulation of hematopoietic stem cell proliferation • negative regulation of mast cell apoptotic process • positive regulation of Ras protein signal transduction • negative regulation of apoptotic process • MAPK cascade • positive regulation of DNA replication • cell adhesion • positive regulation of myeloid leukocyte differentiation • positive regulation of mast cell proliferation • neural crest cell migration • embryonic hemopoiesis • positive regulation of cell proliferation • extrinsic apoptotic signaling pathway in absence of ligand • positive regulation of peptidyl-tyrosine phosphorylation • ovarian follicle development • ectopic germ cell programmed cell death • cell proliferation • phosphatidylinositol-mediated signaling • signal transduction • positive regulation of GTPase activity • phosphatidylinositol phosphorylation • regulation of phosphatidylinositol 3-kinase signaling Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4254	17311
Ensembl	ENSG00000049130	ENSMUSG00000019966
UniProt	P21583	P20826
RefSeq (mRNA)	NM_003994 NM_000899	NM_013598 NM_001347156
RefSeq (protein)	NP_000890 NP_003985	NP_038626.1 NP_001334085 NP_038626
Location (UCSC)	Chr 12: 88.49 – 88.58 Mb	Chr 10: 100.02 – 100.1 Mb
PubMed search

1EXZ, 1SCF, 2E9W

4254

17311

ENSG00000049130

ENSMUSG00000019966

P21583

P20826

NM_003994
NM_000899

NM_013598
NM_001347156

NP_000890
NP_003985

NP_038626.1
NP_001334085
NP_038626

Stem cell factor (also known as SCF, KIT-ligand, KL, or steel factor) is a cytokine that binds to the c-KIT receptor (CD117). SCF can exist both as a transmembrane protein and a soluble protein. This cytokine plays an important role in hematopoiesis (formation of blood cells), spermatogenesis, and melanogenesis.

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Wikipedia