State Road 50 (Florida)
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Major highways in Florida with SR 50 in red.
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| Route information | ||||
| Maintained by FDOT | ||||
| Length: | 114.269 mi (183.898 km) | |||
| Existed: | 1945 renumbering () – present | |||
| Major junctions | ||||
| West end: |
 US 19 in Weeki Wachee
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 I-75 near Brooksville US 27 in Clermont I-4 in Orlando
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| East end: |
 US 1 in Titusville
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| Location | ||||
| Counties: | Hernando, Sumter, Lake, Orange, Brevard | |||
| Highway system | ||||
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| Location: | Brooksville |
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| Location: | Bayport – Weeki Wachee |
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| Location: | Minneola – Killarney |
State Road 50 (SR 50) runs across the center of the U.S. state of Florida through Orlando, with its termini at SR 55 (US 19) at Weeki Wachee and SR 5 (U.S. Route 1) in Titusville.
SR 50 is signed east–west. Within various counties throughout the state, the highway is signed with various names; such as Cortez Boulevard in Hernando County, and Colonial Drive in Orange County. The former section includes the concurrency with US 98 between Brooksville and near Ridge Manor. US 98-SR 50 is the only interchange with Interstate 75 in Hernando County.
Several portions of SR 50 east of SR 436 follow the original Cheney Highway, which was named for John Moses Cheney and was the first road to the coast from Orlando. Full travel from Orlando to Titusville on the Old Cheney Highway, however, is not possible due to the demolition of a bridge over the Econlockhatchee River. At the eastern terminus of SR 50, NASA's Vehicle Assembly Building is visible.
State Road 408, also known as the East-West Expressway or Toll Road 408, from its western starting point near Ocoee, Florida to its eastern terminus near the University of Central Florida near Bithlo, Florida, runs almost directly parallel to SR 50, with most exits on the 408 being within a mile to 2 miles away from SR 50. The East-West Expressway was originally designed to, and still does, relieve traffic congestion on SR 50 during rush hour.
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