Stapleton is a neighborhood in northeastern Staten Island in New York City in the United States. It is located along the waterfront of Upper New York Bay, roughly bounded on the north by Tompkinsville at Grant Street, on the south by Clifton at Vanderbilt Avenue, and on the west by St. Paul's Avenue and Van Duzer Street, which form the border with the community of Grymes Hill. Stapleton is one of the older waterfront neighborhoods of the borough, built in the 1830s on land once owned by the Vanderbilt family. It was a long-time commercial center of the island, but has struggled to revive after several decades of neglect following the building in 1964 of the Verrazano-Narrows Bridge, which shifted the commercial development of the island to its interior.
The neighborhood was the site of the farm where Cornelius Vanderbilt grew up, at the location of the present-day Paramount Theater building on Bay Street (the theater itself having closed in the early 1980s). In the early 19th century it became the commercial center of Southfield Township. In 1832 William J. Staples, a merchant from Manhattan for whom the neighborhood is named, as well as Minthorne Tompkins, the son of Vice President Daniel D. Tompkins, acquired land from the Vanderbilts and laid out the streets. Staples and Tompkins started a ferry service from the neighborhood waterfront to Manhattan and began advertising their new village in 1836.
Seaman's Retreat, a hospital for sailors entering New York Harbor, opened in 1832 and later became Bayley Seton Hospital, the largest employer in the neighborhood until the Sisters of Charity, an order of Roman Catholic nuns which operated the facility, closed it in 2004. (The property is sometimes reckoned as being in Clifton, Stapleton's neighbor to the south.) It was also for many years the site of a United States Public Health Service hospital.