Spain participated in the Eurovision Song Contest 2016 with the song "Say Yay!" written by Bárbara Reyzábal, Rubén Villanueva and Víctor Púa Vivó. The song was performed by Barei. The Spanish broadcaster Televisión Española (TVE) organised the national final Objetivo Eurovisión in order to select the Spanish entry for the 2016 contest in , Sweden. Six artists and songs competed in the televised show where an in-studio jury, an international jury and a public televote selected "Say Yay!" performed by Barei as the winner.

As a member of the "Big 5", Spain automatically qualified to compete in the final of the Eurovision Song Contest. Performing in position 19, Spain placed twenty-second out of the 26 participating countries with 77 points.

Prior to the 2016 contest, Spain had participated in the Eurovision Song Contest fifty-five times since its first entry in 1961. The nation has won the contest on two occasions: in 1968 with the song "La, la, la" performed by Massiel and in 1969 with the song "Vivo cantando" performed by Salomé, the latter having won in a four-way tie with France, the Netherlands and the United Kingdom. Spain has also finished second four times, with Karina in 1971, Mocedades in 1973, Betty Missiego in 1979 and Anabel Conde in 1995. In 2015, Spain placed twenty-first with the song "Amanecer" performed by Edurne.

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