Soyuz TM-7 was the seventh manned spacecraft to dock with the Soviet Space Station Mir. Its launch in November 1988 represented the start of the fourth long duration expedition, Mir EO-4, as it carried two more Soviet cosmonauts, Sergei Krikalyov and Alexander Volkov, to the station. They would join the third crew member of EO-4, cosmonaut/physician Valeri Polyakov, who was on Mir for the second half of EO-3. Also launched by Soyuz TM-7 was French astronaut Jean-Loup Chrétien, who would take part in the 24-day French mission known as Mir Aragatz. The spacecraft Soyuz TM-7 remained docked to Mir for the duration of EO-4. At the end of EO-4 in April 1989, due to delays in the launch schedule, Mir was left unmanned, and all three EO-4 crew members were transported back to Earth.

The original launch date of November 21 was moved back to permit French president François Mitterrand to view the launch, which was also attended by David Gilmour and Nick Mason of Pink Floyd, who made an audio recording of the event for potential use in a future project. The spacecraft arrived at the Mir station carrying a three-man crew, including French cosmonaut Chrétien on his second flight into space. Titov, Manarov, and Chrétien returned to Earth in Soyuz TM-6. Alexander Volkov, Sergei Krikalev, and Valeri Polyakov remained aboard Mir. On 1989 April 28, they left Mir in mothballs and returned to Earth in Soyuz-TM 7. The Soyuz-TM land landing system is effective at reducing velocity in the vertical direction. However, according to cosmonaut Sergei Krikalev, winds at the landing site often impart considerable horizontal velocity. As a result, about 80 percent of all Soyuz descent modules come to rest on their sides. During the rough landing, Krikalev suffered a minor injury to his knee.

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