Sodium-glucose transport protein 2

SLC5A2
Identifiers
Aliases	SLC5A2, SGLT2, solute carrier family 5 member 2
External IDs	OMIM: 182381 MGI: 2181411 HomoloGene: 2289 GeneCards: SLC5A2
Gene location (Human) Chr. Chromosome 16 (human) Band 16p11.2 Start 31,483,002 bp End 31,490,860 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 F3 Start 128,265,657 bp End 128,272,430 bp
Gene ontology Molecular function • low-affinity glucose:sodium symporter activity • symporter activity • transporter activity • glucose:sodium symporter activity Cellular component • integral component of membrane • plasma membrane • extracellular exosome • membrane • integral component of plasma membrane Biological process • carbohydrate transport • ion transport • glucose transmembrane transport • sodium ion transport • transmembrane transport • hexose transport • transport • carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6524	246787
Ensembl	ENSG00000140675	ENSMUSG00000030781
UniProt	P31639	Q923I7
RefSeq (mRNA)	NM_003041	NM_133254
RefSeq (protein)	NP_003032	NP_573517
Location (UCSC)	Chr 16: 31.48 – 31.49 Mb	Chr 16: 128.27 – 128.27 Mb
PubMed search

6524

246787

ENSG00000140675

ENSMUSG00000030781

P31639

Q923I7

NM_003041

NM_133254

NP_003032

NP_573517

The sodium/glucose cotransporter 2 (SGLT2) is a protein that in humans is encoded by the SLC5A2 (solute carrier family 5 (sodium/glucose cotransporter)) gene.

SGLT2 is a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. SGLT2 is the major cotransporter involved in glucose reabsorption in the kidney.

SGLT2 inhibitors are called gliflozins. They lead to a reduction in blood glucose levels. Therefore, SGLT2 inhibitors have potential use in the treatment of type II diabetes. Gliflozins enhance glycemic control as well as reduce body weight and systolic and diastolic blood pressure. The gliflozins canagliflozin, dapagliflozin, and empagliflozin may lead to euglycemic ketoacidosis. Other side effects of gliflozins include increased risk of (generally mild) genital infections, such as candidal vulvovaginitis.

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Wikipedia