Sir John William Maclure, 1st Baronet (22 April 1835 – 28 January 1901), was a British businessman and Conservative politician.
Maclure was educated at Manchester Grammar School and Brasenose College, Oxford, but left university without taking a degree due to ill health. He later became manager of the Guardian Insurance Company and was also Secretary of the Cotton Famine Relief Fund during the Lancashire Cotton famine in the early 1860s. He played an important role for the revival of Conservatism in Manchester and served as President of the Conservative Association of South and East Lancashire. In the 1885 general election he unsuccessfully contested Stretford, but was successfully returned for the same constituency in the 1886 general election, and held the seat until his death. In 1898 he was created a Baronet, of The Home in Whalley Range near Manchester in the County Palatine of Lancaster. He died in January 1901, aged 65. In his memory, his family paid for a stained-glass window placed in the clerestory of the nave of Manchester Cathedral in June 1902.
His brother, Edward Craig Maclure was Dean of Manchester from 1890 to 1906.