"Sick, Sick, Sick" is a single released by Queens of the Stone Age from their 2007 album Era Vulgaris. It was released on May 8, 2007 as a digital download only from the U.S. iTunes Store. The song features Julian Casablancas of The Strokes on backing vocals and synth guitar. An EP called Sick, Sick, Sick was also given a limited release, containing the song and three B-Sides: "I'm Designer" (remix), "Goin' Out West" (Tom Waits cover), and "Christian Brothers" (Elliott Smith cover).

In a May 2007 interview with Dose magazine, frontman Josh Homme stated, "[Sick, Sick, Sick] is the Fairy God Prince of the Gutter, touching everyone on the head and releasing them from their shackles of guilt."

The song appears in a 3-song pack, along with other Queens of the Stone Age songs "Little Sister" and "3's and 7's", as downloadable content for the music video game series Rock Band. It also appears on the soundtrack of the game MotorStorm: Pacific Rift and is playable in Guitar Hero: Van Halen. Along with "Make It wit Chu", it was featured in the Warren Miller documentary Playground.

Director Brett Simon shot a video for "Sick, Sick, Sick" on April 25, 2007. It features the band performing "at a dinner party, audience of one" at a "remote homemade... church-castle in East LA. Michael Shuman, Josh Homme and Troy Van Leeuwen are all playing Ampeg Dan Armstrong Plexi guitars in the video.".

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