"Make It wit Chu" is the third single by Queens of the Stone Age from their 2007 album Era Vulgaris. The song was originally a track on The Desert Sessions Volumes 9 & 10, entitled "I Wanna Make It wit Chu" and with PJ Harvey on backing vocals; it also appeared on the band's live DVD Over the Years and Through the Woods before being rerecorded for their fifth studio album.

"Make It wit Chu" was announced as the second German single in a newsletter from www.qotsa.de and that it would be released on three limited editions on September 28, 2007. It was also confirmed as the band's next international single as well. According to a report by the NME the B-sides for the single would be the "White Wedding" cover, previously released as a bonus track for Era Vulgaris, and a recording of "Needles in the Camel's Eye" from Brian Eno's Here Come The Warm Jets. Bobby Gillespie is reported to have been involved in the latter according to an interview with the band on SuicideGirls.

At the 2007 MTV Video Music Awards, Josh and Troy, along with Cee Lo Green (on vocals) and Dave Grohl (on drums), played the song in The Palms Casino Hotel, in one of the Fantasy Suites. This song was #60 on Rolling Stone's list of the 100 Best Songs of 2007.

At the end of the song, a keyboard can be heard which starts at about 4:31. This is the same tune played during the chorus of the song Era Vulgaris, which was left off the album of the same name.

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