The gens Sempronia was a Roman family of great antiquity. It included both patrician and plebeian branches. The first of the Sempronii to obtain the consulship was Aulus Sempronius Atratinus, in 497 BC, the twelfth year of the Republic. The patrician Sempronii frequently obtained the highest offices of the state in the early centuries of the Republic, but they were eclipsed by the plebeian families of the gens at the end of the fourth century BC. The glory of the Sempronia gens is confined to the Republican period. Very few persons of this name, and none of them of any importance, are mentioned under the Empire.
The praenomina favored by the patrician Sempronii were Aulus, Lucius, and Gaius. The plebeian families of the gens used the praenomina Gaius, Publius, Tiberius, and Marcus. The Sempronii Tuditani used Marcus, Gaius, and Publius, while their contemporaries, the Sempronii Gracchi, used Tiberius, Gaius, and Publius. Some families, including the Sempronii Rutili and Sempronii Muscae, used the praenomen Titus instead of Tiberius.
The Sempronii were divided into many families, of which those bearing the surname Atratinus were undoubtedly patrician, while all of the others appear to have been plebeian. Their names were Asellio, Blaesus, Densus, Gracchus, Longus, Musca, Pitio, Rufus, Rutilus, Sophus, and Tuditanus. Of these, only Atratinus, Gracchus, and Pitio occur on coins.
Atratinus is derived from , meaning "clad in black". The Atratini were patricians, and were distinguished in the early history of the Republic; but after the year 380 BC, no member of the family is mentioned till 34 BC.