Selamectin

Selamectin

Clinical data
Trade names	Revolution, Stronghold
AHFS/Drugs.com	International Drug Names
Routes of administration	Topical
ATCvet code	QP54AA05 (WHO) QP53BX55 (WHO)
Identifiers
CAS Number	220119-17-5 N
PubChem CID	9578507
ChemSpider	16738655 N
UNII	A2669OWX9N
ChEMBL	CHEMBL160777 N
Chemical and physical data
Formula	C43H63NO11
Molar mass	769.96 g/mol
3D model (Jmol)	Interactive image
SMILES C[C@H]1CC[C@]2(C[C@@H]3C[C@H](O2)C/C=C(/[C@H]([C@H](/C=C/C=C/4\CO[C@H]\5[C@@]4([C@@H](C=C(/C5=N/O)C)C(=O)O3)O)C)O[C@H]6C[C@@H]([C@H]([C@@H](O6)C)O)OC)\C)O[C@@H]1C7CCCCC7
InChI InChI=1S/C43H63NO11/c1-24-11-10-14-30-23-50-40-36(44-48)27(4)19-33(43(30,40)47)41(46)52-32-20-31(16-15-25(2)38(24)53-35-21-34(49-6)37(45)28(5)51-35)54-42(22-32)18-17-26(3)39(55-42)29-12-8-7-9-13-29/h10-11,14-15,19,24,26,28-29,31-35,37-40,45,47-48H,7-9,12-13,16-18,20-23H2,1-6H3/b11-10+,25-15+,30-14+,44-36-/t24-,26-,28-,31+,32-,33-,34-,35-,37-,38-,39-,40+,42+,43+/m0/s1 N Key:AFJYYKSVHJGXSN-XHKIUTQPSA-N N
NY (what is this?)

Selamectin (trade names Revolution, Stronghold) is a topical parasiticide and anthelminthic used on dogs and cats, distributed by Zoetis, a former Pfizer subsidiary. It treats and prevents infections of heartworms, fleas, ear mites, sarcoptic mange (scabies), and certain types of ticks in dogs, and prevents heartworms, fleas, ear mites, hookworms, and roundworms in cats. It also removes 2 types of lungworm in cats (Aelurostrongylus abstrusus, Eucoleus aerophilus) and one type of lungworm in dogs (Eucoleus aerophilus). It is structurally related to ivermectin and milbemycin. Selamectin is not approved for human use.

The drug is applied topically. It is waterfast, and does not lose its effectiveness with bathing. It is packaged according to its varying dosage sizes, and is applied once monthly.

Selamectin disables parasites by activating glutamate-gated chloride channels at muscle synapses. Selamectin activates the chloride channel without desensitization, allowing chloride ions to enter the nerve cells and causing neuromuscular paralysis, impaired muscular contraction, and eventual death.

The substance fights both internal and surface parasitic infection. Absorbed into the body through the skin and hair follicles, it travels through the bloodstream, intestines, and sebaceous glands; parasites ingest the drug when they feed on the animal's blood.