Secretoneurin
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| Aliases | CHGB, SCG1, chromogranin B | ||||||
| External IDs | OMIM: 118920 MGI: 88395 HomoloGene: 1375 GeneCards: CHGB | ||||||
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| Species | Human | Mouse | |||||
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| Location (UCSC) | Chr 20: 5.91 – 5.93 Mb | Chr 2: 132.78 – 132.8 Mb | |||||
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Secretoneurin, is a 33-amino acid neuropeptide derived from secretogranin II (chromogranin C, CHGC). It is also called secretogranin-1.
It is cleaved into the following 3 chains:
Secretoneurin is involved in chemotaxis of monocytes and eosinophils (comparable in potency to interleukin 8) and endothelial cells and in regulation of endothelial cell proliferation. Highest secretoneurin levels are found in anterior pituitary, followed by adrenal medulla and posterior pituitary hypothalamus (2- to 6-fold lower levels in other brain regions investigated). Secretoneurin has been shown to have potent angiogenic activity in vivo in mouse cornea model and in vitro in a 3-dimensional gel. Secretoneurin also stimulates dopamine release from the central striatal neurons and basal ganglia.
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