SCG2

SCG2
Identifiers
Aliases	SCG2, CHGC, EM66, SN, SgII, secretogranin II
External IDs	MGI: 103033 HomoloGene: 2591 GeneCards: SCG2
Gene ontology Molecular function • chemoattractant activity • cytokine activity • protein binding Cellular component • extracellular region • dense core granule • secretory granule • extracellular space • neuronal dense core vesicle Biological process • protein secretion • induction of positive chemotaxis • negative regulation of endothelial cell apoptotic process • eosinophil chemotaxis • positive chemotaxis • negative regulation of extrinsic apoptotic signaling pathway • intracellular signal transduction • inflammatory response • positive regulation of endothelial cell proliferation • endothelial cell migration • angiogenesis • MAPK cascade • negative regulation of endothelial cell proliferation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7857	20254
Ensembl	ENSG00000171951	ENSMUSG00000050711
UniProt	P13521	Q03517
RefSeq (mRNA)	NM_003469	NM_009129 NM_001310680
RefSeq (protein)	NP_003460	NP_033155.1 NP_001297609 NP_033155
Location (UCSC)	Chr 2: 223.6 – 223.6 Mb	Chr 1: 79.43 – 79.44 Mb
PubMed search

7857

20254

ENSG00000171951

ENSMUSG00000050711

P13521

Q03517

NM_003469

NM_009129
NM_001310680

NP_003460

NP_033155.1
NP_001297609
NP_033155

SCG2, also called secretogranin II (chromogranin C), is a protein which in humans is encoded by the SCG2 gene.

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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